Hi there- I am new to these boards and have been ill for two years. This past 6 months CFS has tried to take my life away and unfortunately it is being to take it away. My house is a wreck, my poor children don't do anything anymore, I am getting ready to lose my occupation therefore my home will follow and god knows what else. I am not scared for me but I am terrified for my children. I cry everyday until I have a headache that I can not handle anymore. I really hope that one day I will get better but it doesn't seem that many do although there is so many protocols. I'm desperate and up to trying everything. Anyway, I am wondering for the people who take Xyrem or who take Pregablin how long either or both of these drugs take to find out if they work or not? I am going to call my doctor on Monday and have him prescribe them for me and I will report back. He is open to everything. Thanks for your answers and your help!