In the May 26, 1999 issue of JOURNAL Of The AMERICAN MEDICAL ASSOCIATION, doctors Teitelbaum, Weiss, and Bird took issue with a recent study using cortisol (hydrocortisone) to treat CFS. They pointed-out the safety and effectiveness of using LOW-DOSE versions of this all-important "stress-hormone" to treat CFS, and that the study in question didn't follow this protocol. The study, previously reported in JAMA, had made other serious errors and as a result, thought this form of treatment to be unsafe, despite patients' improvement. In my personal experience some 19 years ago, supplementing with this actual hormone (various forms are available) is the key to treating CFS if; The illness resulted from prolonged stresses, viruses, or injuries, and has many symptoms that are inflammatory, hypoglycemic, and "switched-on fight-or-flight response" in nature. The "mild cortisol-deficiency" which is the big issue, doesn't necessarily show in standard testing. CFS is nothing new; "unexplained chronic-fatigue" has been around as long as we humans have had adrenal glands. Sometimes we need to look back at the basics-I've been out of this scene a long time and am surprised at all the complicated detours and blind-alleys so many CFS patients are on these days!