Has anyone ever tried small theraputic doses of hydrocortisone to treat CFS? I came across this information when I was researching natural progesterone cream to treat menopause and pms symptoms. According to Dr. John Lee, CFS and other immune diseases could have to do with adrenal gland exhaustion. Small doses of hydrocortisone (not predisone or other steroids)can help with CFS symptoms. I have suffered for 15 years with CFS and it all started with a horrible bout of flu. I have not been the same since. These are my symptoms: Easily stressed out, fatigue, low tolerance for exercise, the heat of summer drains me and I cannot stand the hot sun on my skin, plus many more. I am new to this board and so far I have enjoyed reading the posts. By the way Dr. John Lee's book is about menopause but he does mention the book by William McK. Jefferies (Safe Uses of Cortisol). I haven't read it yet but I'm going to. Good health to all and I'll keep you all updated on the hydrocortisone.