Hello anyone: I have started on low dose naltrexone, 4.5 mg. I have been feeling much better and so quickly too. My problem now is that I think 4.5 is too much to start with. I think 2.5 to 3 mg might be better to start with because I feel a bit shakey more internal than external. If I get up and move around a lot that improves. (What is this, new found energy I am not used to having??) Here are some immediate things that have improved on the 9 days of using this drug: 1. much less depression 2. much less fatigue 3. I don't have the feeling that my body weighs 10 tons 4. I actually smile and can see some humor everyday. 5. I do not reach for a pain pill first thing in a.m. I have fibromyalgia compounded by spinal spurs, degenerative disc disease, 5 bulging discs, no thyroid (forever hypothyroidism), GERD, Raynaud's syndrome and maybe hypoglycemia. I do not have rheumatoid arthritis, osteoporosis etc. I think this is a possible helpful therapy for fibro and/or CFS. I would like to talk to anyone who is on this. I had a panic attack while driving yesterday and wonder if this caused it. It could have been the coke I drank on an empty stomach.....?? Any answer is welcome and thanks.