I began it last week, 50 mg, which I change every 3 days. I must say I have really noticed such an improvement. My pain has really lessoned and I am thrilled. He gave me 5mg percocet in case, but so far I have not needed it. I take ativan for sleep, the patch, lexapro, and soma and percocet if needed. I sure hope this patch keeps working. I wanted to share this news. Hugz and best wishes friends.