I have been diagnosed with FMS for a little over 1 year now, but believe that I've had it for nearly 24 years (I'm 56). I have two questions: (1) For most of these years, I've had IBS, and it hasn't been uncommon for me to have episodes of "not making it" during the day. This has caused the greatest disruption in my life, especially during the earlier years. However, recently I've had more "flare ups" of the FMS with many symptoms that are fairly common witht the disease. One thing that has happened that is fairly new to me is that I've had bowel incontinence at night or while I sleep. Has anyone had this happen? In the past, My physician (GI) has placed me on Questran (Cholestyramine), but I would stop it after it caused the opposite effect, constipation. I tried cutting the Questran in half, but never could get just the right dose to do what I thought it should. My other physician (IM) has told me to use various OTC meds, but have had same effect. (2) Has anyone had a similar problem with bowel incontinence and / or periods of "not making it" and found a better solution? My husband wants me to get Depends. I told him I'd "rather die than wear diapers" (I know that sound odd, but this has been a real fear all these years).