I had read that taking tylenol daily vs ibuprofen is actually harder on the kidneys, and of course if you drink alcohol its completely a bad combo.......however I am finding that taking ibuprofen daily I seem to be getting kidney/bladder symptoms, more frequency of urination and more urgency to go--can't "hold" it as long; and pee smells sorta bad if don't flush everytime (sorry for the detail)------ any medical savvy people know the bottom line? For me I know it would be best not to take either one daily if don't need to but unfort. have to pick one in my pain med, don't make it without one of those. I don't drink or do drugs other than some benadryl for sleep. I had seen in a nurse's study though that people that take tylenol daily even without o.d. ever tend to have more kidney failure in general in old age than those that don't and a pain mngmt doc once told me years ago not to take tylenol daily if possible, but it seems no one worries about that these days.....but am not liking the ibuprofen daily either.