Igenex results in...please help

Discussion in 'Lyme Disease Archives' started by liberty143, Apr 25, 2008.

  1. liberty143

    liberty143 New Member

    Helloooo...
    finally could afford test..here are results..
    could y'all help interpret them?

    IFA, B Burgdorferi G/M/A 1:40 titer (indeterminate)

    Lyme, IgG Western Blot (Igenex negative)
    18 kDa neg
    22 kDa neg
    23-25 kDa neg
    28 kDa neg
    30 kDa neg
    31 kDa Indeterminate
    34 kDa neg
    39 kDa indeteminate
    41 kDa positive (*)
    45 kDa neg
    58 kDa positive (*)
    66 kDa neg
    73 kDa neg
    83-93 kDa neg

    Lyme IgM Western Blot

    18 kDa neg
    22 kDa neg
    23-25 kDa indeterminate
    28 kDa neg
    30 kDa neg
    31 kDa double positive (**)
    34 kDa neg
    39 kDa indeterminate
    41 kDa positive (*)
    45 kDa neg
    58 kDa neg
    66 kDa neg
    73 kDa neg
    83 - 93 kDa positive (*)

    Doesn't seem that reactive...
    Thanks for your input.
    liberty
  2. bunnyfluff

    bunnyfluff Member

    is ONLY for Lyme, as well as 31. Other than that, you would have to have syphillis, and I'm guessing that you don't.


    Welcome to the Die Lyme Die Club!

    Bunny
  3. bunnyfluff

    bunnyfluff Member

    don't understand why 2 months later you "still aren't sure" it's Lyme.


    Bunny
  4. buttercakes

    buttercakes New Member

    It sure looks positive for lyme to me, Id say this is the answer you have been waitng for. Are you going to a LLMD?
    Sandie
  5. bunnyfluff

    bunnyfluff Member

    See below:






    Lyme Disease Often Missed as a Cause of Chronic Fatigue Syndrome.


    1. Over 75% of patients with chronic Lyme are negative by ELISA

    WESTERN BLOT
    1. Reflects antibody response to specific Bb antigens
    2. Different sensitivities and specificities of the bands
    3. Some bands are potentially seen in different bacteria- “nonspecific bands”
    4. Some bands are specific to spirochetes
    5. Some bands are specific to Bb
    6. Specific: 18, 23-25, 28, 31, 34, 37, 39, 58, 83 & 93
    7. Spirochetes in general: 41 (flagellum)
    8. First immune response if present is usually 41 and 23 KD bands
    9. Response to the 31 KD proteins is not usually seen for a year after initial infection





    REVISED CRITERIA WITH WB

    1. IGG WB: 2 specific band criteria has demonstrated improved sensitivity and maintained specificity

    2. Can diagnosis Lyme if any one band (IgG or IgM) of 18, 23, 28, 39 or 58 kDa or if any 2 or more of the following bands are present; 30, 45,41 and 93

    3. If negative or require further confirmation, can obtain IGENEX WB (adds specific bands of 31, 34 an 83, which are typically seen in chronic disease)

    4. Positive if any one band of 18, 23, 28,31,34, 39, 58 or 83

    5. If positive for Borrelia on any test, consider testing for neurotoxins

    6. Consider testing for co-infections (discussed below)