Dorothy Wall is a writer and teacher. She came down w/ CFS in 1980 following a bout of mononucleosis two years earlier. The book is both her personal story and a history and discussion of the DD. Published 2005. She says there are tests to document CFS. It's just that doctors don't do them. For example, a blood test developed in Belgium shows an abnormal enzyme (RNase-L) in CFS patients. And blood flow tests show we are not getting enough blood flow to the brain. SPEC scans of the brain show CFS patients and AIDS dementia patients look similar; very unlike healthy brain scans. An afterward by a doctor says CFS involves problems in the brain, the immune systen, the neuroendocrine system and the autonomic nervous system. (Well no wonder it's complicated.) Thanks to KHolmes for recommending the book.