I'm taking too many meds, and two of my docs have suggested that it was hard to tell which symptoms were caused by my disease and which were caused by the meds. My rheumy has suggested I start going down and off some of my meds. The problem is, every time I stop a med, the symptoms it was supposed to relieve come back (well, almost every time). I did go down from two hydroxizines to one, with no problem. Does anyone have any suggestions on how to go off meds, or which meds might be less significant? Or maybe do you have suggestions of supplements I might take instead of a specific med.? A few of the meds are nonnegotiable, because I can get very sick without them, so I'll tell you which ones those are. Here's the list. Sorry to do this to you guys, but i hope you can help. clonazepam (about 2 a day) helps RLS, sleep, and myoclonic jerks Rozerem (2) for sleep Armour Thyroid for hypothyroid, nonnegotiable Trimipramine (kind of like Elavil) 2 a night, for sleep, depression, and pain Singulair, once a day, for severe allergies 1/2 Ambien, for sleep (5 mg.) Lyrica 100 mg. 3 times a day for Fibro. Hydroxizine for bladder problems, 1 at bed Megestrol, 20 mg. 2 times a day for hot flashes and night sweats Elmiron, nonnegotiable, for Interstitial Cystitis (saves me from having to be catherized to have pain drugs injected into my bladder) Ultram, as needed for pain; also Tylenol and ALeve fludrocortisone, for orthostatic hypotension (feel faint when I stand up) Cymbalta, 60 mg. for depression and pain (works great as an antidepressant for me) Provigil, just started for narcolepsy (keep falling asleep all the time otherwise) B12 injections, for energy Sudafed PE, for allergies Nasacort and Astelin inhalers, for allergies. Zyprex (?) for allergies. Prilosec, for acid reflux disease (used to take Aciphex, which helped more), but Prilosec is OTC. I think that's it. Fifteen or twenty years ago, I never even took an aspirin. I only took vitamins. I used to be a vegetarian, and tried to go the natural route in most things. I still believe in this mode of thought. Also, my father was a prescription drug addict (although he would take a good deal more than was prescribed). I'm having major medication guilt. Can you guys help?