Has anyone gradually lost their appetite and become totally unable to eat (anorexic) and severe nausea? I have had FM for many years and have been taking Duragesic patches, Topamax, Wellbutrin, Vioxx, and Ambien for sleep. My Doctor is going on the theory it is drug related so far, but running other tests to cover his bases. Stopped the Topamax as it can reduce appetite but just that hasn't cured me yet. I have NEVER had a problem eating. I was over 200 lbs. and have lost 40 since Sept. and 5 in the last 5 days. I also reduced the dosage of my patch since I am suspicious that the narcotic might be to blame. (Don't want to d/c the patch as it is so helpful for my pain.) Many thanks to everyone for your help, virgomrs.