Immunological abnormalities as potential biomarkers in Chronic Fatigue

Discussion in 'Fibromyalgia Main Forum' started by quanked, May 31, 2011.

  1. quanked

    quanked Member

    Journal of Translational

    Immunological abnormalities as potential biomarkers in Chronic Fatigue
    Syndrome/ Myalgic Encephalomyelitis
    Journal of Translational Medicine 2011, 9:81 doi:10.1186/1479-5876-9-81

    ISSN 1479-5876
    Article type Research
    Submission date 1 April 2011
    Acceptance date 28 May 2011
    Publication date 28 May 2011
    Article URL



    Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is characterised by severe prolonged fatigue, and decreases in cognition and other physiological functions, resulting in severe loss of quality of life, difficult clinical management and high costs to the health care system. To date there is no proven pathomechanism to satisfactorily explain this disorder. Studies have identified abnormalities in immune function but these data are inconsistent. We investigated the profile of markers of immune function (including novel markers) in CFS/ME patients.


    We included 95 CFS/ME patients and 50 healthy controls. All participants were assessed on natural killer (NK) and CD8+T cell cytotoxic activities, Th1 and Th2 cytokine profile of CD4+T cells, expression of vasoactive intestinal peptide receptor 2 (VPACR2), levels of NK phenotypes (CD56bright and CD56dim) and regulatory T cells expressing FoxP3 transcription factor.


    Compared to healthy individuals, CFS/ME patients displayed significant increases in IL-10, IFN-?, TNF-?, CD4+CD25+ T cells, FoxP3 and VPACR2 expression. Cytotoxic activity of NK and CD8+T cells and NK phenotypes, in particular the CD56bright NK cells were significantly decreased in CFS/ME patients. Additionally granzyme A and granzyme K expression were reduced while expression levels of perforin were significantly increased in the CFS/ME population relative to the control population. These data suggest significant dysregulation of the immune system in CFS/ME


    Our study found immunological abnormalities which may serve as biomarkers in CFS/ME patients with potential for an application as a diagnostic tool.