I just wanted to add my two cents to the whole DHEA debate since that last thread seemed to take a different turn although I really can't say I minded the whole discussion on dialectics I will not be presenting scientific evidence, and n does = 1 here, but as TigerLilea pointed out, it is foolish to ignore all anecdotal evidence. After all, that is a huge part of what this forum/message board entails. It would be nice if we could go on PubMed and find conclusive comprehensive studies on every single drug and supplement as it relates to CFIDS, but as we all know far too well, there has been a relative paucity of research on this illness. So, we can wait for decades for all the research to come out, or we can be savvy analysts and draw our own conclusions from a combination of both scientific data and feedback from other PWCs. Anywho, just wanted to say that I too believe that DHEA can potentially be helpful for those who have tested low in DHEA. CFIDS is after all a neuroENDOCRINOLOGICAL immunological disease. One must weight the risks of low DHEA levels against those of supplementation. Just as an example, some studies have shown an inverse correlation between DHEA levels and carotid atherosclerosis in men. I think there is definitely danger in supplementing to the point where DHEA levels become artificially high, and the types of dosages you see out there (25 even 50 mg) can effect that. However, I've found for myself, that I can tolerate a small dose of 5mg, and I want to point out, that it has been essential that this dose be administered in extended release form to more naturally mimic the body's natural hormonal processes. I've found this to be the case with hydrocortisone too. Both of these hormones can make me feel awful in the regular non-extended release form, but are actually quite helpful as XR. Again, I am still cautious of all hormones replacement therapy especially where cancer risks are concerned, but I think it would be dangerous to ignore the possible benefit in helping those of us whose hormone and prohormone levels have been severely affected by this illness. P.S. For those who like their hard science, a meta analysis of literature regarding DHEA demonstrated "some impairment in the majority [of those with CFIDS]" although with several major caveats: http://www.fratellonemedical.com/upload/pdf/CFSreview.pdf This of course doesn't say anything about the efficacy or safety of DHEA treatment.