I has found that when i am getting a migraine and I take an imitrex. It will help my headache but it makes my fibro pain WAAAAYYY worse and makes my heartburn get really bad! the imitrex does something with the serotonin in the brain....and it kicks the fibro up a notch...so if I can notice this and I am just an untrained person, why can't some researcher look at this and make a medicine that can reverse the process? it would probably cause migraines but if you made the opposite of the imitrex, couldn't you fix the fibro??? anyone else notice that they feel super achey after taking imitrex? I just wish someone would just fix this so we could have our lives back..... i am in the camp, obviously that fibro is related to brain chemicals and feel that my fibro was caused by constant, chronic stress that just wore out my ??? my "dopomine maker" and now I dont' make enough dopomine.... just an interesting observation and a wish!