interferon activity in bacterial infection

Discussion in 'Fibromyalgia Main Forum' started by tansy, Sep 5, 2005.

  1. tansy

    tansy New Member

    Nat Rev Immunol. 2005 Sep;5(9):675-87.

    The Yin and Yang of type I interferon activity in bacterial infection.

    Decker T, Muller M, Stockinger S.

    Max F. Perutz Laboratories, University Departments at the Vienna
    Biocenter, Department of Microbiology and Immunobiology, University of
    Vienna; Dr. Bohr-Gasse 9/4; A-1030 Vienna, Austria.

    Interferons (IFNs) are cytokines that are important for immune
    responses, particularly to intracellular pathogens. They are divided
    into two structurally and functionally distinct types that interact with
    different cell-surface receptors.

    Classically, type I IFNs are potent
    antiviral immunoregulators, whereas the type II IFN enhances
    antibacterial immunity. However, as outlined here, type I IFNs are also
    produced in response to infection with other pathogens, and an
    increasing body of work shows that type I IFNs have an important role in
    the host response to bacterial infection.

    Strikingly, their activity can
    be either favourable or detrimental, and can influence various immune
    effector mechanisms.

    PMID: 16110316 [PubMed - in process]
    [This Message was Edited on 09/05/2005]