Male - 43 yrs old. I have had issues with intermittent fatigue and weakness for 8 months. In addition to fatigue, I have intermittent weakness to the point of walking slowly and trouble going up stairs. I walk with a cane on the bad days. Strangely enough, I often improve at night about 8:00 or 8:30 p.m. only to have it come back the next morning. I may have severe trouble going up steps in the afternoon only to feel just fine that evening. This cycle repeats itself often. Sleep is non-restorative. Isocort (cortisol supplement) sometimes will help in reducing the weakness, but not the fatigue. Does it help as an anti-inflammatory and not necessarily because I am low on cortisol? All blood tests are normal. My doctor and an Infectious Specialist have not figured it out. I get to feeling better at times, but it usually doesn't last more than a couple of days. Has anybody else experienced the extreme leg weakness? I am currently working a referral to a neurologist. Thanks for your time.