In the article by Dr. flechas on Oxytocin also on the PH frontpage. Also here http://www.alternative-therapies.com/openaccess/ATHM_19-4_Flechas.pdf He also discusses the importance of iodine in FM. I suspect that what is happening with both oxytocin and iodine therapy is that the micro-circulation is improved and the A-V shunting which is known to be a correlate of pain/neuropathy in FM is being reduced so improving the micro-circulation, in turn this would reduce neuropathic pain, muscle fatigue and muscle cramping. Over time this could also influence energy levels via decreased muscle fatigue. I also suspect that some of the immune system pathology in FM is caused by the very same A-V shunting and lowered micro-circulation because this affect on micro-circulation will cause constant "minor" damage in the peripheral tissues provoking an immune response. In addition the removal of toxins from muscle tissue and other tissues would be impaired. Obviously this can't be the full story because Treg production is affected in FM as it is in ME/CFS and changes to micro-circulation does not explain the effect of Treg production. However I see a recent article showing how Bcells are a major influence on Treg production by the Thymus. The thymus is a gland which is markedly affected by reduction in micro-circulation, similarly to the way breast tissue is affected. In this case the thymus may not be getting the required delivery of Bcells and so inturn the output of Tregs is reduced. Oxytocin is known to improve glandular micro-circulation not only to the mammary glands but to all glandular tissue including lymphatics. Very interesting indeed.