Hi, i was wondering if anyone has exprienced what i have gone through. i have huge problem with tiredness i have low thyroid. my naturopath put me on natural thyroid and isocort. It is starting to look like the isocort cortisol made me gain a lot of weight.it is supposed to be helping with my thyroid but its making me gain weight. It really helps with tiredness , its the only thing that has worked for my fatigue. is this possible that it made me gain weight? Not only that but when i am taking it, i have a hard time losing weight.