I'm a 29 year old lady, formerly fairly active and athletic, who's had cfs and fibro for 14 mo. My most bothersome symptom is leg weakness and for the past 6 months I've been on crutches most of the time, although tests of my muscle power don't show much actual weaknes. Still, my legs feel very weak. Recently another fm patient,who seemed quite knowledgeable about the disease, speculated to me that there is a chemical imbalance in the brain that causes me to get the sensation that my legs are weaker than they actually are or something like that. This almost makes sense, since my neuro workup and muscle biopsy were negative. Anyone else have an opinion or information about this idea?