Doing a search reveals that the topic of nightshades is rarely brought up. I've had FMS since 2000 and for the past 2+ years have had almost 100% success with elimination of FMS symptoms, simply by avoiding the nightshade family of foods. I've done enough experimentation (usually accidentally) to confirm that it really is the nightshades that cause my FMS symptoms. No doubt about it, at least for me since this treatment doesn't work for everyone. The nightshades include the following: - Tomatoes - Potatoes - Peppers (NOT black pepper!) of any kind including that which has been converted into some kind of seasoning e.g. curry. - Paprika - Eggplant Early on, I suspected nightshades but I was unsuccessful at getting better by avoiding them. Why? Because, I was only partially avoiding them -- I stopped eating baked potatoes and spaghetti sauce. Didn't help a bit. As it turns out, it is probably necessary for 100% avoidance if it is going to be effective. Peppers and paprika are the hardest to avoid since they are used as seasonings and are often hidden in the ingredients list simply by being listed as "natural flavorings" or "spices" -- both of which often (usually?) mean that peppers or paprika is in there. Should I "mess up", the effect is noticed between 24-48 hours after I eat the offending food. The effect is a sudden instantaneous onset of bad pain particularly in my legs -- and I do mean sudden! I can be just standing there minding my own business doing nothing, then suddenly it hits! It normally takes 1-2 weeks for the symptoms to subside, and oddly they subside almost as suddenly as they appeared. Other people will vary, but I have observed the onset of symptoms from the following: - Peppers (in ANY form) - Potatoes - Paprika hidden in Miracle Whip mayonaise. I have not yet observed the effect with tomatoes but I normally avoid them anyway, just in case it takes more accumulation for it to happen. It was nightshades that first brought on my FMS. What happened was that 6 weeks before the first symptoms, I got married. My new wife baked potatoes and made spaghetti with sauce on it ALL THE TIME, things that I rarely ever did on my own. It is VERY difficult to successfully avoid these nightshades, but I must because I can now function normally. Many a time I was so affected by pain that I couldn't even so much as walk around a mall and had to wait in my car while my wife shopped for me (how embarassing -- I was only in my early 30's for crying out loud). This year, I've done about a dozen day hikes up sizable mountains in NH and Maine, and was fine afterwards. Anyway, as I was saying, they are difficult to avoid... employees at restaurants usually cannot understand the specifics of my questions/requests. My wife gets annoyed at me for having trouble picking out places to eat while on vacation and the details of how food must be prepared. Most processed foods have to be avoided due to the "spices" ingredient in them. I strongly urge all FMS patients to consider avoiding nightshades. You may have to do it for 3 months or longer to notice an improvement, and even then it may still take longer. A book by Dr. Sherry Rogers called "Pain Free in Six Weeks" (the title is a bit misleading and it'll probably take longer) claims 75% success rate by avoiding nightshades, but other than that I have no idea how reliable it'll really be for everyone. NOTE: This isn't ALL I do -- I have a bunch of supplements I take and if I avoid them for an extended period of time, I start to feel not quite as good. These are fish oil (Fisol), C, E, multi, B-complex, calcium/magnesium, and MSM. Plus I try to stay low on the refined carbohydrates.