Somewhat controversial I guess. Read what I found. Pregabalin Pregabalin is a pain reliever manufactured by Pfizer. In clinical trials of Pregabalin there were reports of mice developing tumors. This led Pregabalin manufacturer to cancel further studies of the drug in humans. Despite these serious Pregabalin adverse effects the drug continues to be studied and Pfizer is planning on submitting a New Drug Application to the FDA by the end of 2002. Milnacipran A review of the studies comparing milnacipran, placebo and active comparator antidepressants provides clear-cut evidence of its efficacy in both severe and moderate depression in hospitalized and community settings. Meta-analyses of the original data of controlled trials involving 1032 patients, comparing milnacipran with imipramine or selective serotonin reuptake inhibitors (SSRIs), show that milnacipran provides antidepressant efficacy similar to that of imipramine and significantly superior to that of the SSRIs. An analysis of a database of over 3300 patients shows that both the general and cardiovascular tolerability of milnacipran are superior to those of the tricyclic antidepressants (TCAs) with fewer cholinergic side-effects.