Discussion in 'Chit Chat' started by therealmadscientist, Nov 18, 2007.

  1. therealmadscientist

    therealmadscientist New Member

    (Posted this also on depression board.)

    Some recent very promising results with treatment resistant depression with ketamine. Still preliminary, but offers research into a new approach to depression.

    Also, some good results with new medicines for hepatitis C. One company, Vertex, had a 12 out 12 cure rate in a four week treatment protocol.

    Your Mr Bill

  2. victoria

    victoria New Member

    How pts got almost instant relief from ADs when combined with ketamine (within hours!), rather than having to wait weeks and weeks...

    But even the article I read then said no one sees ketamine being rx'd anytime soon, no matter how effective, but that the research 'will show' researchers which way to go with their work.

    You'd think they'd at least do it in a hospital setting, but who knows.

  3. therealmadscientist

    therealmadscientist New Member

    Was ketamine injected or was it rubbed on ears I wonder. I've drawn blood from a few rabbit ears.

    Yes, ketamine has been mainly modified into an illegal street "club drug". Wonder if that's why not much research. The antidepressant affect is apparently much longer acting, perhaps a week, than the immediate effects. Never tried it personally, of course.

    [This Message was Edited on 11/19/2007]
  4. victoria

    victoria New Member

    Ketamine is also used in low doses for pain such as that from RSD and from cancer... seems to be especially helpful in emergency cases like car accidents.

    It seems that if used wisely/judiciously, it definitely has some important uses. Like any drug of course, not everyone has a good response to it... and painkillers especially of course have the potential for abuses.

    Widipedia had an interesting article:

    It's apparently quite good for pain from cancer and RSD/Reflex Sympathetic Dystrophy, aka CPRPS/Complex Pain Regional Pain Syndrome

    In light of those who would like to theorize that people with FM have it because they are depressed, rather than they are depressed because they have pain and fatigue What I found really interesting was this paragraph:


    "When treating patients suffering from complex regional pain syndrome (CRPS) with a low-dose (subanesthetic) ketamine infusion, it was observed that some patients made a significant recovery from associated depression.

    "This recovery was not formally documented, as the primary concern was the treatment of the patient's pain.

    "Needless to say, it was not possible to quantify to what degree depression recovery was secondary to the patient's recovery from CRPS. Based on this result, it was thought that a low-dose (subanesthetic) infusion of ketamine was worth a trial in patients who were suffering from treatment-resistant depression without other physical or psychiatric illness."

    Also interesting:

    "Ketamine is being used as a experimental and controversial treatment for Complex Regional Pain Syndrome (CRPS) also known as Reflex Sympathetic Dystrophy (RSD). CRPS/RSD is a severe chronic pain condition characterized by sensory, autonomic, motor and dystrophic signs and symptoms. The pain in CRPS is continuous, it worsens over time, and it is usually disproportionate to the severity and duration of the inciting event. The hypothesis is that ketamine manipulates NMDA receptors which might reboot aberrant brain activity."


    Once a drug gets a 'rep' tho on the street, it seems like those truly in need get cut off quickly, sadly. It's hard to keep it in the right hands, yet it's not right to not use something that can help someone, imho.

    all the best,