This is from a newsletter I received from Dr. Conley. Anyone have any experience (or thoughts) on Kusapressin? A VALUABLE ANTIVIRAL IS NOW AVAILABLE AGAIN Kutapressin is a liver extract that has antiviral activity against many viruses including epstein-barr (EBV), cytomegalovirus (CMV), herpes simplex (HSV), and herpes zoster (shingles HZV). I used to use Kutapressin quite often for the chronic active viral infections that can be part of CFIDS/FM. Many patients in the past have responded very well to Kutapressin injections and since it is natural, the possible side effects were mild. (we will talk about the fact that I have found Kutapressin that is topical: that is applied to the skin, so daily injections are no longer needed). Even though Kutapressin is a liver extract it does not contain iron...therefore is of no help in anemia. What it does contain is amino acids and peptides that have been shown to have anti-viral activity. It has also been shown to have anti-inflammatory activity. Since it is a natural substance (made from pork liver) research has not been conducted on exactly how/why these compounds have anti-viral and anti-inflammatory functions. It has been thought that since pigs and humans get many of the same viruses, the pigs may produce anti-viral peptides that are not species specific and therefore we can use them. In any case, in the past, I have used Kutapressin with considerable sucess in those patients who did not get improvement with oral antivirals such as Zovirax, Valtrex, or Famvir. In 2002 the only manufacturer of Kutapressin stopped making it and it was no longer available. Now however it is back and best of all we are able to have it made into a topical cream that is stronger than the old injectable and appears to work just as well or even better. The topical appears to work better because it builds up a resevoir in the fat of our skin and releases over the course of 24 hours. This gives more consistent release of the medication and better anti-viral activity. Since the shots were just once per day patients would get anti-viral activity for several hours but then would be without any activity for considerable periods of the day.