thumbs up right now it was a really bumpy ride the first couple weeks. I think that was because I had been on daily analgesics for years, sort of hard to quit your pain meds for 3 days and then go on LDN, it probably induced some w/d. In addition as I am beginning to tolerate it better I am finding that .5 mg is good for now, a very small dose, so the higher dose back then was also causing some trouble I think. If I keep tolerating it ok I will play with trying to raise dose but first want to just have a couple good weeks where I am at, this is the first decent week. If you werent on pain meds before it may not be as hard of an adjustment to try if anyone is pondering it. So far it is helping with pain as well as pain meds were and thats cool, its nice not to have to worry about taking medication throughout the day, just once in evening with this. I am sort of spacy now though not sure what that is about,hope I get sharper,actually sometimes I am, its pretty up and down yet.A nice effect is some things are more vibrant to me, ie when walking my dog the trees and flowers and birds singing really stood out more than usual, sounds corny but was cool. I found a european based forum about LDN and interestingly they recommended starting out at .5 mg vs. 3 or 4.5mg if any doubt or side effects, whereas U.S. forums were not so clear about that message at all; leave it to the americans for excess. MOre is not nec. better especially with cfids type stuff. Anyway I was glad for the validation/guidance from the overseas based forum. I also found that a little phosphatidyl has been a savior from rich's simplified plan for when I feel edgy, takes the edge off and I think a little folapro helps if too dopey. I am taking all of this really slow so hard to say for sure yet what is doing what, trying to isolate things at times so can tell what supplement meds are responsible for effects. I went off LDN for almost a week until midlastweek to make sure all the pain med was out of me after I had bad backlash of pain and then started in about a week ago at this .5mg and its been alright, a little better every day, and cut back on supplements til this week slowly adding in. Anyway I highly recommend trying LDN but if you are super sensitive start out low so you don't get turned off to it.