Leaky gut and larch arabinogalactan

Discussion in 'Fibromyalgia and ME & Chronic Fatigue Syndrome' started by meditationlotus, Nov 1, 2005.

  1. meditationlotus

    meditationlotus New Member

    Has anyone tried larch arabiongalactin to help with leaky gut and food allergies?

    It is also supposed to be a great immune modulator.

    Thanks.
  2. baby-bear

    baby-bear New Member

    I have not heard of this but I will look it up. What do you do for reactions to food? Like how do you get rid of the pain and fatigue with headaches?????? Or can you?

    Just wondering...

    Also, I'm starting to really get to where I can only eat about 6-8 things. Thanks

    Pamela
    [This Message was Edited on 11/01/2005]
  3. tansy

    tansy New Member

    Larch Arabinogalactan
    Alternative Medicine Review, Oct, 2000

    Introduction

    Larch arabinogalactan is a polysaccharide powder derived from the wood of the larch tree (Larix species) and comprised of approximately 98 percent arabinogalactan. Arabinogalactans are found in a variety of plants but are more abundant in the Larix genus, primarily Larix occidentalis (Western Larch).

    The Western Larch is unique among pines in that it loses its needles in the fall. Western Larch is also known as Mountain Larch or Western Tamarack and is native to the Pacific and Inland Northwest United States as well as parts of British Columbia, Canada.[1]

    Larch arabinogalactan is approved by the U.S. Food and Drug Administration (FDA) as a source of dietary fiber, but also has potential therapeutic benefits as an immune stimulating agent and cancer protocol adjunct.

    Description and Biochemistry

    Pharmaceutical-grade larch arabinogalactan is a fine, dry, off-white powder with a slightly sweet taste and mild pine-like odor. It dissolves completely in water or juice, is low in viscosity and therefore easy to administer, even to children. It is composed of galactose and arabinose molecules in a 6:1 ratio, with a small amount of glucuronic acid.

    Arabinogalactans are long, densely branched polysaccharides of varying molecular weights (10,000-120,000). Lower molecular weight polysaccharides typically exhibit an anti-inflammatory, anti-complement, antiallergy effect, while those of higher weights stimulate natural killer (NK) cell cytotoxicity and reticuloendothelial cells. In the case of larch arabinogalactan, molecular weights of the two major fractions are 16,000 and 100,000, perhaps accounting for its wide range of therapeutic properties.[2]

    Pharmacokinetics

    Human studies on the pharmacokinetics of larch arabinogalactan are few and the amount absorbed following an oral dose remains unclear. Animal studies indicate that intravenous injection of purified larch arabinogalactan results in 52.5 percent of the dose being present in the liver and 30 percent in the urine 90 minutes after dosing. Hepatic clearance occurred with a half-life of 3.42 days.

    [3] Non-absorbed larch arabinogalactan is actively fermented by intestinal microfiora and is particularly effective at increasing beneficial anaerobes such as Bifidobacteria and Lactobacillus.[4]

    Clinical Indications

    Dietary Fiber

    Larch arabinogalactan is an excellent source of dietary fiber that is able to increase short-chain fatty acid production (primarily butyrate) via its vigorous fermentation by intestinal microflora.[2]

    It is well documented that butyrate is essential for proper colon health as it is the preferred substrate for energy generation by colonic epithelial cells.[5] Butyrate also acts as a protectant for the intestinal mucosa against disease and cancer-promoting agents.[6] Arabinogalactan added to human fecal homogenates has also been shown to decrease ammonia generation, and therefore may be of clinical value in the treatment of portal-systemic encephalopathy, a disease characterized by ammonia build-up in the liver.[4]

    Larch arabinogalactan given to human subjects increased levels of beneficial intestinal anaerobes, particularly Bifidobacterium longum, via their fermentation specificity for arabinogalactan compared to other complex carbohydrates.[7,8]

    Cancer Protocols

    Larch arabinogalactan may be an effective adjunct to cancer therapies due to its ability to stimulate NK cell cytotoxicity, stimulate the immune system, and block metastasis of tumor cells to the liver.[2] Tumor metastasis to the liver is more common than to other organ sites, probably due to tumor cell specificity for lectin-like receptor sites found in liver parenchyma.

    Animal studies have demonstrated arabinogalactan's ability to inhibit or block lectin receptor sites, thereby reducing tumor cell colonization of the liver and also increasing survival time of the subjects.[9-11]

    Pretreatment with larch arabinogalactan was found to stimulate NK cell cytotoxicity via potentiation of the cytokine network, primarily via an increase in the release of gamma interferon.[12]

    Pediatric Otitis Media

    Recurrent otitis media is common in pediatric populations and it appears that improving immune system function might lead to a decrease in both frequency and severity of this condition. Research has demonstrated larch and other arabinogalactans to be capable of enhancing the immune response to bacterial infection via stimulation of phagocytosis, competitive binding of bacterial fimbriae, or bacterial opsonization. This was found to be particularly true for infection by gram negative organisms such as Escherichia coli and Klebsiella species.[2,13]

    In addition, D'Adamo reports a decrease in occurrence and severity of otitis media in pediatric patients supplemented prophylactically with larch arabinogalactan.[2] Larch arabinogalactan's mild taste and excellent solubility in water and juice make it a relatively easy therapeutic tool to employ in pediatric populations.

    Chronic Disease

    A number of chronic diseases are characterized by decreased NK cell activity, including chronic fatigue syndrome,[14] viral hepatitis,[15,16] HIV/AIDS,[2] and autoimmune diseases such as multiple sclerosis.[17] Stimulation of NK cell activity by larch arabinogalactan has been associated with recovery in certain cases of chronic fatigue syndrome.

    [18] Viral hepatitis (hepatitis B and C) is also characterized by a decrease in NK cell cytotoxicity[15,16] and therefore these patients may benefit from its stimulation by larch arabinogalactan. In the case of multiple sclerosis, a small 2-year study of patients with the relapsing/remitting type concluded that disease severity was correlated with NK cell functional activity, supporting the hypothesis that NK cells play a role in the immunopathogenesis of this disease.[17] Consequently, stimulation of NK cell cytotoxicity might be of clinical benefit to these patients.

    Patients with HIV/AIDS develop low CD4 cell counts and often are plagued by opportunistic infections. By virtue of its immune-stimulating properties, larch arabinogalactan has been shown to effect a slight increase in CD4 cell counts, in addition to decreasing susceptibility to opportunistic pathogens.[2]

    Hepatic Drug Delivery

    Hepatic uptake of an injected dose of larch arabinogalactan resulted in 52.5 percent of the dose arriving in the liver. Due to its high hepatic concentration and its ability to increase vascular permeability,[19] larch arabinogalactan has been suggested as a vehicle for administering diagnostic or therapeutic agents to the liver.[3]

    Platelet Washing Medium

    Larch arabinogalactan solution has been studied as a medium for use in platelet washing; a technique employed to separate platelets from platelet-rich plasma. The washed platelets can then be used in transfusions, bioassays, and research. Platelets washed with larch arabinogalactan solution were free of plasma proteins and retained both normal morphology and function.[20]

    Side-Effects and Toxicity

    Larch arabinogalactan is a safe and effective immune-stimulating phytochemical. It is FDA-approved for use as a dietary fiber and in food applications. Both acute and long-term toxicity studies in rats and mice reveal no evidence of toxicity.[21] Human consumption is usually without side-effects; however, a small percentage of people ([is less than] 3%) experienced bloating and flatulence, possibly due to the vigorous fermentation of the arabinogalactan by intestinal microflora.[2]

    Because of its excellent safety profile and solubility in water and juice, larch arabinogalactan is considered a safe, effective immunestimulating agent for pediatric use.

    Dosage

    Larch arabinogalactan in powder form is typically dosed in teaspoons or tablespoons at a concentration of approximately 4-5 grams per tablespoon. The typical adult dosage is one to three tablespoons per day in divided doses; the pediatric dose is one to three teaspoons per day. The powder is usually mixed with water or juice but can be added to food if desired.

    References
    [1.] Odonmazig P, Ebringerova A, Machova E, Alfoldi J. Structural and molecular properties of the arabinogalactan isolated from Mongolian larchwood (Larix dahurica L.). Carbohydr Res 1994;252:317-324.
    [2.] D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-37.
    [3.] Groman EV, Enriquez PM, Jung C, Josephson L. Arabinogalactan for hepatic drug delivery. Bioconjug Chem 1994;5:547-556.
    [4.] Vince AJ, McNeil NI, Wager JD, Wrong OM. The effect of lactulose, pectin, arabinogalactan, and cellulose on the production of organic acids and metabolism of ammonia by intestinal bacteria in a faecal incubation system. Br J Nutr 1990;63:17-26.
    [5.] Roediger WE. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 1989;83:424-429.
    [6.] Tsao D, Shi Z, Wong A, Kim YS. Effect of sodium butyrate on carcinoembryonic antigen production by human colonic adenocarcinoma cells in culture. Cancer Res 1983;43:1217-1222.
    [7.] Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
    [8.] Slavin J, Feirtag J, Robinson R, Causey J. Physiological effects of arabinogalactan (AG) in human subjects. Unpublished research.
    [9.] Hagmar B, Ryd W, Skomedal H. Arabinogalactan blockade of experimental metastases to liver by murine hepatoma. Invasion Metastasis 1991;11:348-355.
    [10.] Beuth J, Ko HL, Oette K, et al. Inhibition of liver metastasis in mice by blocking hepatocyte lectins with arabinogalactan infusions and D-galactose. J Cancer Res Clin Oncol 1987;113:51-55.
    [11.] Beuth J, Ko HL, Schirrmacher V, et al. Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan. Clin Exp Metastasis 1988 ;6:115-120.
    [12.] Hauer J, Anderer FA. Mechanism of stimulation of human natural killer cytotoxicity by arabinogalactan from Larix occidentalis. Cancer Immunol Immunother 1993;36:237-244.
    [13.] Reith FJ. Pharmaceuticals containing lactic acid derivatives and Echinacea. Bundesrepublik Deutsches Patentamt 27 21 014 11/16/78. [German Patent]
    [14.] Levine PH, Whiteside TL, Friberg D, et al. Dysfunction of natural killer activity in a family with chronic fatigue syndrome. Clin Immunol Immunopathol 1998;88:96-104.
    [15.] Corado J, Toro F, Rivera H, et al. Impairment of natural killer (NK) cytotoxicity activity in hepatitis C virus (HCV) infection. Clin Exp Immunol 1997;109:451-457.
    [16.] Machado IV, Deibis L, Risquez E, et al. Immunoclinical, molecular and immunopathologic approach to chronic viral hepatitis. Therapeutic considerations. GEN 1994;48:124-132. [Article in Spanish]
    [17.] Kastrukoff LF, Morgan NG, Zecchini D, et al. A role for natural killer cells in the immunopathogenesis of multiple sclerosis. J Neuroimmunol 1998 ;86:123-133.
    [18.] Uchida A. Therapy of chronic fatigue syndrome. Nippon Rinsho 1992;50:2679-2683.
    [19.] Kind LS, Macedo-Sobrinho B, Ako D. Enhanced vascular permeability induced in mice by larch arabinogalactan. Immunology 1970;19:799-807.
    [20.] Hill RJ, Stenberg PE, Sullam PM, Levin J. Use of arabinogalactan to obtain washed murine platelets free of contaminating plasma proteins and appropriate for studies of function, morphology, and thrombopoiesis. J Lab Clin Med 1988;111:73-83.
    [21.] Wagner H. Low molecular weight polysaccharides from composite plants containing arabinogalactan, arabinoglucan, and arabinoxylan. Bundesrepublik Deutsches Patentamt DE 3042491 7/15/82. [German Patent]
  4. mjgkennedy

    mjgkennedy New Member

    Hi Tansy thanks for your excellant post on Leaky Gut which I suffer from along with a lot of other things.

    Did you ever hear of Glutamine?.

    Mary
  5. tansy

    tansy New Member

    Hi Mary

    Despite basic probiotics my GI tract issues got much worse some time ago so I decided that this had to be a priority. I changed to stronger and better probiotics, took alternatives to help my liver and gall bladder, digestive enzymes, herbs to treat various pathogens including candida, + + + and for me the mandatory psyllium husks which I mix with equal quantities of psyllium powder. Flax seed is a no no for me because it triggers colon and bowel spasms; it took a while for me to realise flax seed oil also contributed to my gastritis just as soya milk had done in the past.

    I used glutatmine powder for a few months but stopped because I did not notice any differences and because some specialists became concerned over the use of glutamine in those who have known problems with monosodium glutamate (MSG).

    I made a lot of progress leaky gut wise until I was Rx long term low dose doxy for a chronic middle ear infection when primal defense helped; and then had problems again when taking samento. atm my GI tract is back to functioning well even though I am taking higher doses of the samento.

    IMHO treating leaky gut and restoring good flora in the gut is essential for better health.

    Love, Tansy[This Message was Edited on 11/02/2005]
  6. Dolphin_lover

    Dolphin_lover New Member

    I'm hoping you see this. You mentioned probiotics and leaky gut. I just purchased some goat milk concentrate after reading the article on this website's front page titled "Q & A: Dr. Gloria Gilbere on Treating Immune and Digestive Disorders Naturally". Have you tried this product, and if so, how did it work for you? I have a leaky gut also. This is my first foray into probiotics.

    Thanks for any and all imput
  7. tansy

    tansy New Member

    I have not used this myself, I have only ever been able to semi-tolerate one dairy/milk supp, a 50% IgG colustrum, and that had to be at the lowest dose. When I stopped taking this specific colustrum product I realised I was having problems with that too even though it was to a lesser extent.

    Undenatured whey proteins do help many with these DDs, the goat’s milk ones are considered superior by some practioners, so it’s worth a try.

    Like Mikie I think we should all be taking probiotics, but they are especially important for leaky gut and/or candida.

    Love, Tansy
  8. Dolphin_lover

    Dolphin_lover New Member

    So much for your imput. I was looking some encouraging words and you gave them to me. Thanks again! I'll let you know after a month or so (I hope I have some positive results within that time frame) if it is helping me or not.
  9. meditationlotus

    meditationlotus New Member

    and it seems that it is helping me with my food allergies.
    I've been feeling a little more energy and a sense of well-being.

    Also started taking some pregnenolone, 10 mg. per day at the same time that I started the Larch. Thought it might help my adrenal gland. I'm feeling a little better. Don't know how much to attribute to the larch and how much to the Pregnenolone.