LOSE WEIGHT and MS,RA, Autoimmune disease!

Discussion in 'Fibromyalgia Main Forum' started by darude, Jan 13, 2006.

  1. darude

    darude New Member

    Can't beat that!!!!!!! Wonder if will help us?

    Blocking fat hormone can halt Multiple Sclerosis
    Washington: Italian researchers have found that blocking the hormone leptin, which is primarily produced in fats cells, has beneficial effects on multiple sclerosis (MS).

    Giuseppe Matarese and colleagues from Universit' di Napoli “Federico II” suggest that leptin neutralization may be a potential way to both prevent and treat MS.

    Leptin is known to play a critical role in the regulation of food intake, metabolism, and the immune response. Since it had been previously shown that leptin is expressed in active inflammatory lesions of the central nervous system during EAE and MS, Matarese and colleagues investigated the effects of leptin blockade on the induction and progression of EAE in mice.

    They found that leptin blockade in mice, by the use of either anti-leptin antibodies or a form of the leptin receptor unable to bind leptin, either before or after disease onset improved clinical symptoms of disease, slowed disease progression, reduced disease relapses, and reduced the number of antigen-specific T cells.

    The authors delved further to unravel the cellular signaling events underlying these beneficial effects. Taken together, the data provide a basis for the development and testing of novel strategies of leptin-based targeting for the potential treatment of MS.






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  2. darude

    darude New Member

    Sends me alerts for all sorts of things. I'll go back and check just got it today!
  3. darude

    darude New Member

    It's all over the news today!
  4. darude

    darude New Member

    Naples scientists block peptin to halt progress of disease
    (ANSA) - Rome, January 13 - A hormone used in weight-loss drugs plays a vital role in blocking the development of multiple sclerosis (MS), a team of Italian researchers has discovered .

    A study by scientists from the Naples Federico II University has shown that isolating the hormone in mice halts the progress of the disease .

    Leptin, a peptide hormone produced by fat cells, plays a role in weight regulation and the body's immune response. The findings, published by the prestigious US-based biology review, the Journal of Clinical Investigation, suggest that controlling leptin could also prove the key to future developments in battling MS .

    The team first pinpointed the connection between leptin and MS two years ago, after discovering that levels of the hormone doubled just before the onset of the disease .

    They also found neurons in the brain lesions of diseased mice with MS produced large quantities of leptin .

    They consequently decided to test the effects of isolating the hormone in the brains of diseased mice, blocking it through specific antibodies and receptors .

    The results were extremely promising, with an immediate halt to further progress in the disease. Furthermore, there were far fewer regressions and there was a drop in the number of immune cells associated with MS .

    Perhaps most important of all, the team, led by Giuseppe Matarese, believes the research has uncovered vital information regarding the molecular effects of leptin. Eventually, this could help them develop new techniques for treating the disease .

    MS affects about 2.5 million people worldwide, according to the Multiple Sclerosis International Federation .

    It is a chronic disease of the central nervous system (the brain, optic nerves, and spinal cord) in which a person's immune system attacks his or her own healthy tissue .

    Symptoms vary widely and include blurred vision, weak limbs, tingling sensations, unsteadiness and fatigue. For some people, MS is characterised by periods of relapse and remission while for others it has a progressive pattern. For everyone, it makes life unpredictable .

    MS is a very variable condition and the symptoms depend on which areas of the nervous system have been affected. The faculties commonly affected are: vision, co-ordination, strength, sensation, sexuality, speech and swallowing, bladder control and cognitive functions .

  5. darude

    darude New Member

    Blocking Fat Hormone Might Slow MS

    By Kathleen Doheny
    HealthDay Reporter


    THURSDAY, Jan 12 (HealthDay News) -- Mice with an animal form of multiple sclerosis (MS) displayed slowed disease progression when scientists blocked the activity of a hormone called leptin, found primarily in fat cells.

    The Italian team studied experimental autoimmune encephalomyelitis (EAE) in mice -- a commonly used animal model for researchers investigating MS.

    "We are the first to report that leptin blockage can alter the EAE symptoms in mice," said Dr. Giuseppe Matarese, of the Universita di Napoli in Napoli, Italy. He is the lead author of the report, published in the February issue of the Journal of Clinical Investigation.

    MS is an incurable inflammatory disease of the central nervous system marked by muscle weakness, numbness and loss of coordination. Disease severity can range from the relatively benign to cases involving serious disability and death. Many experts consider MS an autoimmune disease, in which the body attacks its own tissues, especially the protective myelin sheath surrounding nerves. About 400,000 people in the United States are diagnosed with MS, according to the National Multiple Sclerosis Society.

    Leptin is known to play a role in regulating not only food intake and metabolism, but also the body's immune response. The hormone is expressed in active inflammatory lesions of the central nervous system during both MS and its mouse equivalent, EAE, Matarese said. Leptin also seems to increase the secretion of inflammatory mediators that help damage myelin.

    However, using anti-leptin antibodies or disabled leptin receptors, Matarese's team effectively blocked leptin production in mice with EAE. The result: slowed EAE disease progression.

    Blocking leptin reduced the number of disease relapses for the entire follow-up period of 120 days, the team found, suggesting the effect of leptin blockade is long lasting. The mice's "clinical score" -- reflecting symptoms -- was also reduced when leptin was blocked, as were levels of inflammation.

    The new study builds on previous research, Matarese said. "In the past, we also showed that leptin administration to EAE-susceptible mice makes the EAE symptoms and brain inflammatory infiltration worse," he said.

    Because leptin may play a role in other autoimmune disorders, the Italian researcher said his team will extend their work to include mouse models of type 1 diabetes and rheumatoid arthritis. They also plan to study the effects of leptin blockage in MS patients.

    However, a spokesman for the National Multiple Sclerosis Society urged caution when interpreting the findings. Dr. John Richert, vice president for research and clinical programs for the society, said other groups have looked at controlling levels of leptin in blood and have not found differences between those with MS and those without, suggesting that leptin blockage may not become effective treatment.

    Still, he said, the Italian research remains promising. "There is enough information there to indicate it warrants further study, but it's not a slam-dunk that it is going to be useful for people with MS."


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  6. darude

    darude New Member

  7. Rosiebud

    Rosiebud New Member

    thanks for posting. I hope there's a positive outcome eventually, it might help us too.

    love
    Rosie
  8. darude

    darude New Member

    Hope so!