Hi all- I am newish to the board, I have never posted before. I have been diagnosed with a dysautonomia, but suspect that I have other issues going on. A couple of friends suggested I check out this site for a great wealth of knowledge and support. I am not sure that I have CFS, but it is a definite possibility. My dysuatonomia diagnosis really hit a dead end, as my team of doctors don't know much about it. I am seeking an explanation, at this point, to one of the test results I have had returned that I believe holds the key to my issues, if only I can understand it. My doctors all scratched their heads and referred me to someone else at this. I have low normetanephrine levels. This was measured through a 24 hour urine catecholamine test. Normetanephrine is the metabolite of norepinephrine. My doctors suspect that since my levels are quite low, this means that a lot of norepinephrine is going into my blood, which causes a lot of the dysautonomic symptoms, like heart issues. However, I am looking for an explanation as to why these levels are low, and what this could indicate about what is going on!!!! I have recently been turned on to investigating the methylation cycle, which many of you are probably familiar with, since I have read that the enzyme that breaks down norepinephrine into normetanephrine, needs to be methylized in order to function properly. So, I am wondering if anyone here has low normetanephrine levels??? And does anyone know why they do??? I would so greatly appreciate any feedback. Thank you all!!!