Has anyone had any problems with low platelet counts my platelet count has been hovering between 37,000 and 65,000 for almost the past 2 years (Normal low is 140,000). my hematologist believes its all the meds. At the present i am on Trazadone, Wellbutrin, Vioxx, MS Contin, Xanax, Synthroid and Nexium. i recently began Effexor and my count dropped 30,000 over a one month period. My doctor wants me to stop a lot of these meds. has anyone had this problem and if so stopped meds and had improvement. I bruise easily but do not bleed excessively. i have also had Lyme disease several times and there are some who feel that may be the casue. anyone else out there experiencing any of this?