New study from Stricker: --------- "More than 5 years after publication of the Klempner article, the `over-reaching impact' of the study has finally been challenged. Cameron examined the generalizability of the Klempner study findings in terms of the patient cohort, the treatment regimen and subsequent studies of prolonged antibiotic therapy in chronic Lyme disease . Patients in the study cohort had been sick for an average of 4.7 years and had been treated with an average of three courses of antibiotics, making this a `re-treatment' study of patients who had already failed similar therapy. Furthermore, based on the health-related quality-of-life scale that was used, the treatment regimen was inadequate for the degree of functional compromise in these patients in terms of intravenous antibiotic duration and oral antibiotic dose. Cameron concluded that the study represents a `too-little too-late' approach to a highly selected, extensively treated patient group that differs significantly from more typical chronic Lyme patients who are either untreated or undertreated. Based on the lack of generalizability of the study results, the blanket interpretation that long-term antibiotics are ineffective for chronic Lyme disease is invalid ." whole article is available if you google the following (journal plus the title/author): Expert Review of Anti-infective Therapy Turning Point Stricker It's newly out, Oct. 2007 - - Pubmed citation: Expert Rev Anti Infect Ther. 2007 Oct;5(5):759-762. (altho it's in process here, too new) Expert Review of Anti-Infective Therapy October 2007, Vol. 5, No. 5, Pages 759-762. Lyme disease: a turning point Raphael B Stricker and Lorraine Johnson Author for correspondence International Lyme and Associated Diseases Society, 450 Sutter Street, Suite 1504 San Francisco, CA 94108, USA. ilads.org * International Lyme and Associated Diseases Society, PO Box 341461, Bethesda, MD 20827 USA.