Lyme? Psychological effects?

Discussion in 'Lyme Disease Archives' started by justjanelle, Jan 30, 2008.

  1. justjanelle

    justjanelle New Member

    I'm wondering if anyone here knows any good links I can check out about potential psychological manifestations of Lyme Disease?

    Thanks to Munch and the Twins I was able to get my Lyme and Babesia diagnosis in November and am having more good days with treatment.

    But I have started thinking I want my 2 kids to be tested, as they were born after I had the rash and started my earliest symptoms.

    Son has skin hypersensitivity, Photo-phobia, attention and organizational problems. Daughter is having psychological issues including bipolar, depression, sudden rages/crying fits, panic etc.

    Dr. F in Louisiana says I don't need to have them tested. I'd like to get some more information and consider whether I should insist on the testing for them.

    Help? Opinions? Options?

    Thanks!

    Janelle

    [This Message was Edited on 01/30/2008]
  2. victoria

    victoria New Member

    for starters I would go to the org sites for lyme, like ILADS, CanLyme, and others.

    There was a story in 2005 about the FSU star quarterback being found walking down the street in middle of night, mumbling he was God, etc., disheveled... after a month of hospital stay/testing, nothing was found. Ultimately/finally a friend of the family suggested being tested for Lyme.

    You guessed it, he was positive, did IV abx, and was able to return to school in a fairly quick time, altho he did have to stop football.

    Lyme, being the masquerader it is, can show up as anything. The top LLMDs feel that children/adults who have ADD, depression, bipolar, etc., should be evaluated for lyme/co-infections...

    it's not hard to find if you type appropriate words in google, for instance, lyme add depression, or similar.

    My son showed up with neuro symptoms long before his physical symptoms. It would've been easier to diagnose if it'd been the reverse... and may be why he responded paradoxically to any type of psychotropic.

    all the best,
    Victoria

  3. mollystwin

    mollystwin New Member

    It's nice that you have your diagnosis, but now you have to worry about your kids!! I agree with everything Victoria says. I had my neuro symptoms before my physical symptoms too.

    I am also keeping an eye on my youngest son because I know I had lyme when I had him. Today he is home from school and of course I'm in a panic cause he's sick! He is fairly healthy though, so far so good.

    Good luck!!
  4. victoria

    victoria New Member

    something your daughter might want to try in particular is L-theanine, it's an amino acid that really helps with panic or anxiety. I totally forgot, it's what got my son thru a semester of HS 1/2 time without falling apart (anxiety, depression), and helps him even now.

    It also helps one's immune system, btw!

    Here's Wikipedia's report on it:

    Theanine is an amino acid commonly found in tea (infusions of Camellia sinensis). Theanine is related to glutamine, and can cross the blood-brain barrier.[1] Because it can enter the brain, theanine has psychoactive properties.[2] Theanine has been shown to reduce mental and physical stress[3] and may produce feelings of relaxation.[4]

    Theanine is speculated to produce these effects by increasing the level of gamma-aminobutyric acid (GABA) production. Theanine increases brain serotonin, dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors.[5]

    It has also been found that injecting spontaneously hypertensive mice with theanine significantly lowered levels of 5-hydroxyindole in the brain.[6] Researchers also speculate that it may inhibit glutamic acid excitotoxicity.[5] Theanine also promotes alpha wave production in the brain.[2]

    Studies on test rats have shown that even repeated, extremely high doses of theanine cause little to no harmful psychological or physical effects.[7]

    L-theanine may help the body's immune system response when fighting infection by boosting the disease-fighting capacity of gamma delta T cells. The study, published in 2003 by the Brigham and Women's Hospital, included a 4-week trial with 11 coffee drinkers and 10 tea drinkers, who consumed 600 milliliters of coffee or black tea daily. Blood sample analysis found that the production of anti-bacterial proteins was up to five times higher in the tea-drinkers, an indicator of a stronger immune response.[8]

    References

    1. Yokogoshi H, Kobayashi M, Mochizuki M, Terashima T (1998). "Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats". Neurochem Res 23 (5): 667-73. PMID 9566605.
    2. a b Gomez-Ramirez M. "The Deployment of Intersensory Selective Attention: A High-density Electrical Mapping Study of the Effects of Theanine". Clin Neuropharmacol 30 (1): 25-38. PMID 17272967.
    3. Kimura K, Ozeki M, Juneja L, Ohira H (2007). "L-Theanine reduces psychological and physiological stress responses". Biol Psychol 74 (1): 39-45. PMID 16930802.
    4. Lu K, Gray M, Oliver C, Liley D, Harrison B, Bartholomeusz C, Phan K, Nathan P (2004). "The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans". Hum Psychopharmacol 19 (7): 457-65. PMID 15378679.
    5. a b Nathan P, Lu K, Gray M, Oliver C (2006). "The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent". J Herb Pharmacother 6 (2): 21-30. PMID 17182482.
    6. Yokogoshi H, Kato Y, Sagesaka YM, Takihara-Matsuura T, Kakuda T, Takeuchi N (1995). "Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats.". Biosci Biotechnol Biochem. 59 (4): 615-618. PMID 7539642.
    7. Borzelleca J, Peters D, Hall W (2006). "A 13-week dietary toxicity and toxicokinetic study with L-theanine in rats". Food Chem Toxicol 44 (7): 1158-66. PMID 16759779.
    8. Kamath A, Wang L, Das H, Li L, Reinhold V, Bukowski J (2003). "Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses". Proc Natl Acad Sci U S A 100 (10): 6009-14. PMID 12719524.
  5. justjanelle

    justjanelle New Member

    And Victoria, I'm going to check on getting my daughter the L-theanine as well as pushing to get them both tested for Lyme Disease, even if the doctor really doesn't think it's likely.

    Best wishes,
    Janelle
  6. victoria

    victoria New Member

    it's available at health food stores or online, happily, not RX!

    best,
    Victoria