I've been taking Lyrica for almost three weeks now. I'm taking 75mg. twice a day. I saw my Dr. today and told her the only thing I've noticed so far is that I'm nauseated and tired. No relief yet from the pain down the sides of my legs. She commented that most of her patients start to feel relief after a couple of weeks. Oh, and might I mention that my weight has increased 6 lbs. since starting on the Lyrica! My Dr. says that Lyrica has little effect on weight, although I know I've read about it causing weight gain and swollen ankles in some. What are your experiences? Is three weeks too soon to see the benefits? Does the sleepiness decrease sometime soon? I am also feeling very irritable and a bit too emotional(crying)these days. Could it be the Lyrica, or is it just coincidental? When I tried Topomax, I became an emotional wreck and had to stop it. I even tried it again several months later, but had the same problem. I haven't tried Neurontin but thought that Lyrica would be better. Any thoughts on this would be greatly appreciated.