So far it is the ONLY thing that I have noticed giving me UMPH and GO and even making me goofy hyper for a few minutes... before this I was sleeping while awake!! I went without it for a few days while I was out of town and man did I pay!! I got back took one and within three hours I had this new found energy - my boyfriend asked me what was wrong with me I was dancing around the living room! I am sticking with it - I hope my body doesn't become resistent!! Got the idea to try it before actual thyroid meds from this site. so THANK U !! It did take a week or two before initial reaction, but now I am so grateful to have it - it is #1 in my cabinet right now!!