ME/CFS and oxidative stress

Discussion in 'Fibromyalgia Main Forum' started by tansy, Aug 9, 2005.

  1. tansy

    tansy New Member

    Oxidative stress levels are raised in chronic fatigue syndrome and
    are associated with clinical symptoms.

    Journal: Free Radic Biol Med. 2005 Sep 1;39(5):584-9.

    Authors: Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch
    JJ.

    Affiliation: Vascular Diseases Research Unit, The Institute of
    Cardiovascular Research, Ninewells Hospital and Medical School,
    Dundee, Scotland DD1 9SY, UK.

    NLM Citation: PMID: 16085177

    The aetiology of chronic fatigue syndrome (CFS) is unknown; however,
    recent evidence suggests excessive free radical (FR) generation may
    be involved.

    This study investigated for the first time levels of
    8-iso-prostaglandin-F(2alpha)-isoprostanes alongside other plasma
    markers of oxidative stress in CFS patients and control subjects.

    Forty-seven patients (18 males, 29 females, mean age 48 [19-63]
    years) who fulfilled the Centres for Disease Control classification
    for CFS and 34 healthy volunteers (13 males, 21 females, 46 [19-63]
    years) were enrolled in the study. The CFS patients were divided
    into two groups; one group had previously defined cardiovascular
    (CV) risk factors of obesity and hypertension (group 1) and the
    second were normotensive and nonobese (group 2).

    Patients had significantly increased levels of isoprostanes (group
    1, P = 0.007; group 2, P = 0.03, unpaired t test compared to
    controls) and oxidised low-density lipoproteins (group 2, P = 0.02)
    indicative of a FR attack on lipids. CFS patients also had
    significantly lower high-density lipoproteins (group 1, P = 0.011;
    group 2, P = 0.005). CFS symptoms correlated with isoprostane
    levels, but only in group 2 low CV risk CFS patients (isoprostanes
    correlated with; total symptom score P = 0.005; joint pain P =
    0.002; postexertional malaise P = 0.027, Pearson).

    This is the first time that raised levels of the gold standard
    measure of in vivo oxidative stress (isoprostanes) and their
    association with CFS symptoms have been reported.
  2. Mikie

    Mikie Moderator

    To eat well and take antioxidants.

    Thanks, Tansy.

    Love, Mikie