This has been a question that NO doctor as ever been able to answer for me. Why do so many of us suffer from medication sensitivity? Since my FM diagnosis, I have been on only 10 different meds, ALL of these meds had to be removed because of awful side effects that my body just could not tolerate and I am currently not on any meds except for occasional Aleve or Advil. I would think that doctors would be puzzled by this. On the other hand, I have been to FM support groups a few times and some of the people there who have FM are on many medications, so I was confused about this. When I was at a few of these support groups, some of the ladies admitted to a lot of side effects from there medications, but they continued to take them because they just didn't know what else to do. I found this to be disturbing only because I know when I had taken Zoloft, I almost went to the hospital because of reactions, also other drugs I was on caused weight gain severely, muscle relaxers for me caused nightmares and distrubed thinking and sleep, Vioxx was another one I had taken and I felt like I was going to have a heart attack. I can go on and on with these drugs and the problems they have given me. I took only half the dose of Vioxx and it had to be discontinued for me. I would gladly take a med for my FM, but past experience has me so anxious that I don't even pay attention to any new med that comes out, especially the ones targeted for FM, the reason being is that once people go on them, the side effect stories about these drugs just keep pouring in. Or, maybe the drug works for a while, but then people start noticing side effects that are just not acceptable. Anyway, has anyone's doctor ever given you a theory as to why this happens to some of us who try to take meds? There must be something about our body chemistry, or maybe it's something else. By the way, in the past some natural remedies have helped me like magnesium malate, although it doesn't work as well as it used to, this is puzzling to me as well. Any thought? Hugs Chelz.