Where do i start . .I have a question about the drugs I take and if anyone has had the same reactions. I was put on Seroquel, Risperdal, Zoloft, Toprol XL (for MVP) for various reasons too numerous to explain here, but anyways I am always tired now. I sleep for 14-16 hours a day and still get up and am tired. I cut my medication down a little (by half) without the doctor's approval to see if i would be less tired and now i only sleep 12-14 hours a day. Have others had the same experience with these meds. Also, has zoloft caused anyone to develop hypothyroidism. Because that happened to me too and started taking thyroid for it, and i still don't feel any better. I know insomiacs would beat me if they heard me say this "but i want to only sleep 8 hours a night and feel well rested." lol.