Does anyone know if there could be a reaction between 5HTP and the med - Zanaflex. I know there is one if you take both 5HTp and Tramadol. I also wonder how many days it takes for 5HTP to get into your system. I was taking it for being so depressed, but the fibro pain was still so bad that I took 1/2 of Zanaflex - muscle relaxant - last nite and today, esp. this a.m. feel like I was on speed. Now, tonite, for whatever reason, I feel better than I have in so very long, I think. I am doing all I can with diet, no sugar, no white flour, only veggies and fruits, small amount of meat, much liquids, etc. Don't know what is going on. But am wondering if anyone knows about 5HTP, its reactions with other meds, and since I am now afraid to keep taking the 5 htp as I need something for pain when I sleep, will that just leave my system and I will get down again really fast? Please, some help . Thanks.