. Other Causes Of Dry Eyes And Dry Mouth Certain drugs can act on the brain to decrease tear and saliva flow and leads to increase symptoms of dryness. One example is tricyclic antidepressants (Elavil or Pamelor) or muscle relaxing agents (such as Flexeril) that influence the metabolism of certain specific brain cells as well as salivary and lacrimal glands. A different class of medications called monoamine oxidase (known as MAO) inhibitors also give severe dryness. Thus, the patient needs to be aware that many drugs, including anti-seizure medications, blood pressure medications, muscle relaxants, and heart medications, lead to increased dryness by affecting different target molecules within the body. think the flexeril could be my problem!!! took 2 yesterday, also was taking neuronton. Going to start elevil tonight. Might not be sjogrens after all.