Dr. Cutler wrote the book: No Amalgams and is considered my many to be an expert on chelation. This is a synopsis of his protocol: Dr. Andrew Hall Cutler’s Mercury Detox Program: •DMSA alone followed by DMSA + ALA is a reasonable option. •ALA is the only one of the common chelator agents which crosses the blood-brain-barrier, so you need to use ALA at some point in order to clear mercury from the brain. •ALA has specific risks because it crosses the blood-brain-barrier. It is riskier if used soon after mercury exposure (such as soon after amalgam replacement). This should be considered in deciding when to use ALA. •ALA tends to lessen copper excretion--- so people taking ALA may have their copper levels increase. This can be a problem for people who already have high copper (which is toxic). This should be considered in deciding when to use ALA. •DMSA is stressful to the liver. ALA is helpful to the liver. •ALA is sulfury. (This is "good" for some and "bad" for others. If you are a "high sulfur" person, you may need to limit the ALA dose amount and/or limit sulfur foods carefully while chelating with ALA.) Dose frequency: •DMSA: every 4 hours, including at night •ALA: every 3 hours, including at night. (You can stretch it to every 4 hours at night if it helps you get a little more sleep, but go back to every 3 hours during the day.) •DMSA + ALA (together): same as ALA, every 3 hours, including at night. (You can stretch it to every 4 hours at night if it helps you get a little more sleep, but go back to every 3 hours during the day.) •It is generally okay to take a dose SOONER, if this is more convenient. For instance, it is fine to take the next dose of ALA after 2.5 hours rather than 3. If you do this, be sure to adjust the time of the next following dose so that it is taken within 3 hours. (Don't accidentally leave it till 3.5 hours later because of the "early" dose). All dose guidelines are about the LONGEST you can go between doses. Shorter is okay. Dosage: •DMSA (alone or in combination with ALA): 1/8 to 1/2 mg of DMSA per pound of body weight, per dose •ALA (alone or in combination with DMSA): 1/8 to 1/2 mg of ALA per pound of body weight, per dose Ratio of DMSA to ALA (if using both): •A 1:1 ratio seems to work fine. A ratio between 1:2 and 2:1 is best. Length of cycles: •At least a few days on. Three days on or more is recommended. 2.6 days on is acceptable. (3 entire daytimes and the 2 nights in between = 2.6 days.) (Also, Friday after school until Monday morning = 2.6 days.) Less is getting "iffy". •At least as many days off as you had on •There is not an obvious one-size-fits-all answer. The following are all reasonable options: 3 days on, 4 days off. OR 3 days on 11 days off . Many other options are also reasonable. •Two weeks on at most.