Mestinon.....A alternate treatment to Growth Hormone therapy?....

Discussion in 'Fibromyalgia Main Forum' started by AJME, Aug 23, 2003.

  1. AJME

    AJME New Member

    Dear All,

    Excerpt from article Below. I read that Mestinon is currently being tested for FM by the NIH. The article is a little over 1 year old.

    "What caused this growth-hormone defect? The researchers guessed that it might be too much of another hormone -- somatostatin -- which blocks growth hormone."


    Fibromyalgia: A Growth-Hormone Defect?

    By Daniel DeNoon
    WebMD Medical News

    May 3, 2002 -- A new study points to a possible growth-hormone defect in women with fibromyalgia. Researchers are suggesting that a drug currently used to treat a nerve and muscle disorder might be helpful for fibromyalgia.

    The finding comes from a report by Robert M. Bennett, MD, and colleagues at the Oregon Health Sciences University, Portland, in the May issue of the journal Arthritis & Rheumatism.

    FM appears to be a complex illness in which the body's normal means of regulating stress and pain gets out of whack. One of the hormones involved is called growth hormone.

    Bennett's team put 20 women with fibromyalgia and 10 normal women through physical stress by having them run on a treadmill until they were exhausted. They found that growth-hormone levels went up in the healthy women, but not in the women with fibromyalgia.

    What caused this growth-hormone defect? The researchers guessed that it might be too much of another hormone -- somatostatin -- which blocks growth hormone. They did the test again, only this time the women with fibromyalgia exercised after taking a drug that blocks somatostatin. This time, their growth hormone levels went up just like those of the healthy women.

    The drug, Mestinon, currently is used to treat myasthenia gravis, an autoimmune disease in which people suffer attacks of muscle weakness. Bennett and co-workers suggest that it should be studied as a possible treatment for fibromyalgia.

    Other researchers have tested fibromyalgia patients for growth hormone defects. But a common test for growth-hormone defect -- measurement of blood levels of a substance called IGF-1 -- seems not to work for many fibromyalgia patients. Indeed, many of the fibromyalgia patients with growth-hormone defects in the Bennett study had normal IGF-1 levels. The researchers therefore recommend different tests should be used in fibromyalgia patients.

  2. Plantscaper

    Plantscaper New Member

    Bump for any responses>>
  3. Dara

    Dara New Member

    The Fibromyalgia Clinic is headed by Dr. Bennett. My growth hormone is very low so they had me take Mestinon. I think I took it for maybe two or three months but could see no difference. So, next time I went to see my PCP I told him I didn't think it was really working, so he told me to stop taking it. Well, I don't know if this is coincidence or not, but in the past two to three months I've been in one constant flare non stop and have been in a lot of pain. I take plenty of pain meds so I don't think I should be hurting this bad. My next appointment with the FM clinic is in a week or so, I'm going to address the Mestonin again with them.

    As we all know medications affect everyone differently. Just because I didn't feel a change, it might make someone else feel great. Have you been checked for low growth hormone?