Dear All, Excerpt from article Below. I read that Mestinon is currently being tested for FM by the NIH. The article is a little over 1 year old. "What caused this growth-hormone defect? The researchers guessed that it might be too much of another hormone -- somatostatin -- which blocks growth hormone." ******************** Fibromyalgia: A Growth-Hormone Defect? By Daniel DeNoon WebMD Medical News May 3, 2002 -- A new study points to a possible growth-hormone defect in women with fibromyalgia. Researchers are suggesting that a drug currently used to treat a nerve and muscle disorder might be helpful for fibromyalgia. The finding comes from a report by Robert M. Bennett, MD, and colleagues at the Oregon Health Sciences University, Portland, in the May issue of the journal Arthritis & Rheumatism. FM appears to be a complex illness in which the body's normal means of regulating stress and pain gets out of whack. One of the hormones involved is called growth hormone. Bennett's team put 20 women with fibromyalgia and 10 normal women through physical stress by having them run on a treadmill until they were exhausted. They found that growth-hormone levels went up in the healthy women, but not in the women with fibromyalgia. What caused this growth-hormone defect? The researchers guessed that it might be too much of another hormone -- somatostatin -- which blocks growth hormone. They did the test again, only this time the women with fibromyalgia exercised after taking a drug that blocks somatostatin. This time, their growth hormone levels went up just like those of the healthy women. The drug, Mestinon, currently is used to treat myasthenia gravis, an autoimmune disease in which people suffer attacks of muscle weakness. Bennett and co-workers suggest that it should be studied as a possible treatment for fibromyalgia. Other researchers have tested fibromyalgia patients for growth hormone defects. But a common test for growth-hormone defect -- measurement of blood levels of a substance called IGF-1 -- seems not to work for many fibromyalgia patients. Indeed, many of the fibromyalgia patients with growth-hormone defects in the Bennett study had normal IGF-1 levels. The researchers therefore recommend different tests should be used in fibromyalgia patients.