Here is some good info from a reliable "friend" on another health board. Just an FYI, do your research too. ((She decided that 14 years of taking Metformin for Diabetes was LONG ENOUGH, so I switched to the Herb Berberine and have had some great surprises. It works for that and also my Arhythmias have disappeared as well. Here is a page from Dr. Sahelian and emails he has received from users. http://www.raysahelian.com/berberine.html This friend went on to say WHY she wanted off Metformin and basically what disturbed her was the latest newsletter from Dr. Jonathan Wright, (near Seattle ) talking about Metformin and all the side effects and I thought I can do this, so she found some Berberine and started on it and no more Arythmias, digestion better, blood sugar lower and on and on…..