My sister can not take the pills like Imitrex because she gets severe anxiety attacks... so I was ticked to see this article. I hope it's OK to post. I remember we're not suppose to do links... correct? JAMA-Intranasal lidocaine provides rapid relief of migraines Article Source: Unknown Article Date: 3/1/2001 -------------------------------------------------------------------------------- JAMA--Anesthetic lidocaine provides rapid relief of migraines. Nasal drops containing the anesthetic lidocaine can provide quick relief for migraine headaches, though relapses are liekly, according to an article in the July 24, 1996 issue of The Journal of the American Medical Association (JAMA). Morris Maizels, M.D., from the Department of Family Practice, Southern California Permanente Medical Group, Woodland Hills, CA, and colleagues evaluated the effectiveness of intranasal lidocaine for treatment of acute migraine headache. The researchers found: "Intranasal lidocaine provided rapid and effective relief of pain in approximately 55 percent of patients with migraine headache in our urgent care population. Most of the effect occurred within five minutes, and nausea and photophobia (an abnormal sensitivity or intolerance to light) were similarly relieved. For patients for whom follow- up data were available, 42 percent of lidocaine responders had relapse of headache to a moderate or severe intensity." They continue:"The onset of relapse with lidocaine, however, was usually within one hour. For the rest of the group, intransal lidocaine effectively terminated a headache episode without relapse. The rapid relief (as well as rapid relapse in some patients) is consistent with the pharmocological properties of lidocaine." The study included 81 patients (67 women and 14 men) with a chief complaint of headache who fulfilled criteria of the International Headache Society for migraine. Patients were randomized in a 2:1 ratio to receive a four percent solution of intransal lidocaine or saline placebo, respectively. The primary outcome measure was at least 50 percent reduction of headache within 15 minutes after treatment. Reduction in pain intensity of 50 percent was significant within 5 minutes. Complete or near complete relief of headache was seen in 11 (21 percent) of the 53 lidocaine patients and two (seven percent) of 28 control patients. The researchers found that of those participants who received relief within five minutes of using intranasal lidocaine, 58 percent had persistent symptom relief for the 24-hour period follow-up. Adverse effects were limited to local symptoms of burning and numbness in the nose or in and around the eye. An unpleasant taste was often noted. Numbness in the throat was often asociated with a sense of gagging. These local symptoms were noted almost exclusively in the lidocaine group. In a separate interview, Dr.Maizels said it should be taken into account that this was a small study that needs to be replicated on a larger scale to ensure the validity of the results. He added that lidocaine is currently not available commercially as a nose drop. Information in the study says that migraine is a recurrent painful condition that affects approximately 17 percent of adult women and six percent of adult men each year. College Pharmacy compounds an intranasal lidocaine in a 4% solution. It can be ordered by any physician and shipped directly to your home. For more information, please call 1-800-888-9358 or contact us by e-mail at firstname.lastname@example.org.