Mirapex anyone?

Discussion in 'Fibromyalgia Main Forum' started by kimbadee, Dec 31, 2005.

  1. kimbadee

    kimbadee New Member

    Has anyone tried mirapex for fibro? It is approved for Parkinsons disease but have heard good reports for its use for fibro. Anyone have any experience?

    I am new here and I just cannot suffer this winter like I did the last one. Am thinking about trying mirapex but would like some feedback.

    Thanks.

    Happy New Year!
  2. ksc

    ksc New Member

    i've been on it for over 2 yrs. have had great sucess with it. almost all my symptoms are gone. if you look in the library- there is an articale from oct. there. on a scale of 1-10, i was a 10. now i'm aroun 2-3. 4 -5 if i have over done it. there are side effects you have to get past. but it's worth it!
    kathy
  3. kimbadee

    kimbadee New Member

    Thank you for replying. I will check out the article. The only side effect I have read about so far is weight loss. YIPEE!

    Did you start off on an increasing dosage type of therapy?
  4. daquayom

    daquayom New Member

    I have been on Mirapex for about 4 months now and at first I thought it was a godsend! It was like a miracle. Nothing else I has ever tried worked. But about 1 1/2 months ago I started noticing that it wasn't working as well and as of now it is not working at all for me. And I have a real hard time with some of the side affects. (Feeling like I am gonna pass out mainly). I am not saying don't try it or it won't work for you cause everyone is different. It may be the right thing for you. Good luck!
  5. cosmoo

    cosmoo New Member

    Hi, yes I tried it for a short period of time. I could not get past the severe nausea which is a common side effect. You start on a slow dose and work your way up. It is suppose to go away but mine did not and taking the recommended antacids did not help. It also made my sleep -restless legs worse. I do have a friend though who was in the orginal trials and swears she no longer knows she has FM.
    However if you wish some good information, the Dr. who first propsed this is named Andrew J. Holman. He presented a paper at the Amercian College of Rheumatology Annual Meeting in 2000, reporting on his trial uses of mirapex with FM patients. If you want to see the paper and more information on his protocal go to the web and type in Andrew J. Holman. He lives in Renton, WA. I am also from WA.
    I hope you will find it succesful for you many have.Best Wishes
  6. roseylisa

    roseylisa New Member

    I take mirapex but only at nite for the restless leg syndrome I havn't noticed it to help with pain only twitching in my legs that keeps me from sleeping,
    [This Message was Edited on 12/31/2005]
  7. Musica

    Musica New Member

    Here is a portion from an article about the Mirapex study. I also posted Dr. Holman's entire Arthritis & Rheumatism article from August several weeks back, in 2 or 3 posts (the site wouldn't accept it all in one).
    *********

    In response to encouraging results from the use of dopamine agonists for the treatment of restless legs syndrome (RLS), which occurs disproportionately among fibromyalgia (FM) patients, researchers have speculated that this class of agents may play a role in the treatment of fibromyalgia syndrome (FMS).

    Now a new study shows that FM patients taking pramipexole, the dopamine3-receptor agonist developed for the treatment of Parkinson's disease, reported decreased pain and fatigue and improved function and global status compared with study participants taking placebo.1 The new study appears in the August issue of Arthritis and Rheumatism.
    "I am remarkably hopeful for patients with FMS based on treating FMS with dopamine agonists for 5 years and from the results of this study," lead researcher Andrew J. Holman, MD, a rheumatologist at Pacific Rheumatology Associates in Renton, Washington, tells CIAOMed. Dr. Holman has patents for the use of dopamine2 /dopamine3-receptor agonists for the treatment of FM.

    Rationale for the effectiveness of pramipexole
    "It was the disproportionate RLS in FMS [patients] that began to point to this therapy," Dr. Holman says, adding that some researchers believe that the essence of RLS is relevant to FMS. The RLS Foundation in Rochester, Minnesota, estimates that about 20% to 40% of the FM population also has RLS. "The hippocampal inhibition of autonomic arousal appears primary," Dr. Holman says. Some research suggests that disturbed stage four sleep leads to FMS symptoms and that autonomic arousal at night fragments sleep. "The hippocampus inhibits autonomic arousal, [and] dopamine3 receptors control hippocampus function," Dr. Holman explains.

    "Much work remains, but hopefully researchers will continue to report how hippocampal function applies to FMS," he says. "Currently, I hope to repeat the study using sleep studies to document sleep stage architecture improvement." Dr. Holman adds that now "we are completing a cost analysis of FMS care to measure the economic benefits of effective treatment of FMS with dopamine agonists."

    Pramipexole improves pain, function

    In the single-center, double-blind, placebo-controlled study of 60 FM patients, patients received either pramipexole (Mirapex; Boehringer Ingelheim) or placebo for 14 weeks. The drug was initiated at 0.25 mg, titrated to 4.5 mg for the last 3 weeks, and then tapered to 0 mg during week 15. The study medication was taken by mouth each evening.

    Patients were allowed to take concomitant medications, including narcotic analgesics, antiepileptics, nonsteroidal anti-inflammatory drugs, and selective serotonin reuptake inhibitors during the study period as long as the dosage had been stable for at least 6 weeks prior to the study.

    At week 14, the mean decrease in pain from baseline, as assessed by the visual analog scale (VAS), was 36% and 9.4% in the pramipexole and placebo groups, respectively (P = 0.008). Moreover, 42% of patients in the pramipexole group achieved at least a 50% reduction in VAS scores compared with 14% in the placebo arm (P = 0.03). Overall, 82% of patients taking pramipexole noted some improvement in pain compared with 57% of those in the placebo group (P = 0.04). Other scales that measure FM and mental symptoms, such as the Hamilton Depression Inventory and the Multidimensional Health Assessment Questionnaire, also improved in the pramipexole arm.

    No study participants withdrew due to side effects of the study medication. The most common adverse effects were weight loss and nausea. Interestingly, patients did not suffer from any of the side effects seen in patients taking this medication for Parkinson's disease, including hallucinations.

    *************

  8. kimbadee

    kimbadee New Member

    Thank you so much for the information!!

    Take care,
    Kim