Various Causes of Fibromyalgia ( Pseudo fibromyalgia? ) "Classic Fibromyalgia" "Pseudo Fibromyalgia" "Organic Diseases" "Functional Disorders" "Musculoskeletal Disorders" For more information on this there is an excellent article posted on : Dynamicchiropractic.com, Fibromyalgia Syndrome: Reclassification is Definitely Needed. ================================================================= Radio: We need more research in identifying these other subgroups and possible misdiagnosis of FM. We need to ask the right questions in order to have full understanding of the contributing factors to our illnesses. Does Fibromyalgia Run in the Family? "If you suffer from fibromyalgia, you may have wondered how much of the syndrome is genetic. Do your parents endure neck and back pain, chronic fatigue and headaches? Do your brothers, sisters and children exhibit many of the same symptoms of fibromyalgia? Scientists are now closer to understanding why many people in your family may be susceptible to similar painful conditionsand diseases." All in the Genes? "The role of genes in fibromyalgia and related conditions has been the subject of vigorous debate and controversy since the late 1980s. In those years, Dr. Muhammad B. Yunus of the University of Illinois College of Medicine conducted a study of 40 fibromyalgia patients and their families to determine the genetic basis of the illness. Of the families of the 40 fibromyalgia patients, 74% of siblings, 53% of children and 42% of parents had fibromyalgia. Notably, Yunus found a connection between the genetic marker, human leukocyte antigen (HLA), and the development of fibromyalgia." "HLA, a protein found in your body’s cells, is used by the immune system to recognize familiar cells and reject foreign cells. Although people inherit this protein from their parents, its presence does not necessarily indicate a person will develop fibromyalgia. It has since been hypothesized that several genes are working together to create fibromyalgia in certain people." HLA System "The human leukocyte antigen system is the name of a cluster of genes found in our immune system that work to keep foreign pathogens out of our bodies. There are more than 100 human leukocyte antigens. HLA types were once most often studied to find organ donors for organ transplants. HLA is still currently used to find matches for bone marrow transplants." "It is believed that certain HLA types are passed down from generation to generation and can lead to autoimmune disorders such as lupus erythematosus and Sjogren’s Syndrome. Even though fibromyalgia is considered a chronic syndrome,e not an autoimmune disorder, Dr.Yunus used HLA types to infer peoples’ genetic predisposition to the disease. However, scientists in the study were not able to exclude the environment of the family as a predisposing factor to the disease." See more here: Does Fibromyalgia Run In The Family Radio: Do you know your HLA types ? Introduction "Most people know their ABO blood type. In some countries people carry a card indicating their blood type, in case of accident requiring an emergency blood transfusion. Few people however have heard of HLA types (human leukocyte antigens), the antigens in our blood that fight off microbes." "Contrarily to ABO blood types people do not have just one HLA type, but many (about 8 per person). " "There are 3 major types of class I HLA (HLA-A, HLA-B, HLA-C) and 3 major types of class II HLA (HLA-DP, HLA-DQ and HLA-DR). Each type comprises hundreds of subtype (e.g. HLA-B27), further subdivided in hundreds of sub-subtypes (e.g. HLA-B*2705). " "People will usually have 2 types of HLA-A, 2 of HLA-B, and 2 of HLA-C as well as 1 or 2 other types." "HLA types are encoded in the HLA gene on chromosome 6. HLA types are therefore hereditary, just like the ABO blood type." HLA's role in fighting diseases "Each type and subtype is more or less efficient in fighting off viruses and noxious bacteria. There are tens of thousands of possible combinations of HLA, which is why some people never get sick, while other constantly have a cold, or are prone to some types of infections, depending on what HLA combination they have. " "HLA types found in tropical countries tend to differ a lot from those in temperate parts of the world, because the viruses found there are different. Some Africans have developed HLA that give them resistance to malaria, for instance. When the Europeans arrived in the Americas, bringing with them new viruses on the continent, the biggest part of the Native American population of North America was wiped out as they didn't have the right antigens to fight off even the common cold." "But too aggressive HLA's can also be bad for the body. Some HLA types are known to attack the body's own cells, causing what is known as autoimmune diseases, in other words diseases caused by one's immune system attacking one's own body. "See more here: http://www.eupedia.com/forum/threads/25151-HLA-types-and-autoimmune-diseases Radio: I just had a revelation. I was looking at some HLA -B gene testing I had done last week as I believe that HLA testing is the future in identifying subgroups of misdiagnosed FM. I just found out I have the B*44 gene-allele. See links below... "HLA-B44 increases recurrent sinopulmonary infections. Protective effects: HLA-B44 appears to be protective against autoimmune Lymphoproliferative Syndrome in patients with C95 defect (ALPS type Ia). B44 may be a cofactor in ankylosing spondylitis " http://en.wikipedia.org/wiki/HLA-B44 "Other HLA genes have been associated with SpA in IBD: HLA-DrB10103, HLA-B35, HLA-B24 in type 1 peripheral arthritis, and HLA-B44 in type 2 peripheral arthritis" See more here: Enteropathic Spondyloarthritis: From Diagnosis to Treatment "Type II is a polyarthritis mainly affecting the small joints. It rarely precedes the diagnosis of IBD. It tends to run a course independent of the bowel disease. Metacarpophalangeal joints are frequently involved and the differentiation of type II peripheral arthritis and rheumatoid arthritis is important and requires radiographic and immunologic correlation. Approximately half of the patients with IBD have migratory arthritis. Active synovitis may persist for months, and may recur repeatedly. Episodes of exacerbations and remissions may continue for years. Evolution to chronicity may occur together with radiographic erosive lesions . Type II arthropathy affects 3 - 4% of patients with IBD. Type II peripheral arthritis is associated with HLA-B44* in 62% of patients versus 30% of controls . It is also associated with uveitis but not with other extraintestinal manifestations." See more here: Rheumatological manifestations Diagnosing Infective Polyarthritis -pdf Extraintestinal Manifestations? Radio: I have thought about testing to see if anti-collagen antibodies are possibly connected to my passed history with chondritis and the HLA B*44 allele?