Mitochondrial dysfunction can cause hypothyroidism and adrenal dysfunction...

Discussion in 'Fibromyalgia Main Forum' started by ljimbo42, Nov 9, 2014.

  1. ljimbo42

    ljimbo42 Active Member

    There is overwhelming evidence that mitochondrial dysfunction plays a big role in cfs. This article says that mitochondrial dysfunction can cause hypothalamic-pituitary-adrenal axis impairment.

    Which can lead to low levels of thyroid stimulating hormone (TSH) and adrenocorticotropic hormone (ACTH). Low TSH can cause hypothyroidism and low ACTH can cause adrenal dysfunction. This could explain why so many of us have thyroid and adrenal problems! Here is the link-

    Rich Van Konynenburg also made the connection of low ACTH causing lowered cortisol secretion in his paper on "Glutathione depletion-methylation block." Here is a quote from his paper-

    "HPA axis blunting (138): According to this Hypothesis, glutathione depletion in the pituitary gland inhibits production of proopiomelanocortin (POMC) (which has two disulfide bonds in its N-terminal fragment (139)), and hence secretion of ACTH (which is part of POMC), by the same mechanism as inhibition of perforin synthesis (102) (See “Suppression of parts of the immune response,” above.). This results in the lowering of cortisol secretion by the adrenal glands, which is a late finding in the course of the illness (140)."

    Here is a link to Rich's paper-

    I believe that mitochondrial dysfunction is caused by impaired methylation, dysbiosis and leaky gut. So the best way to fix mito. dysfunction is to cut off the source of toxins causing it and dysbiosis and leaky gut are a HUGE source of toxins. A clean diet also has a huge role in healing, I don't think healing is possible for most without a clean, healthy diet.

    To improve mitochondrial function magnesium, coq10 or ubiquinol (reduced coq10), carnitine or acetyl-carnitine, creatine, ribose and NADH will help tremendously. Methylation support should wait until the gut has healed to some degree.This will help reduce over burdening the liver with toxins and causing flares and detox symptoms. All the best-Jim
    RadioFM likes this.