More from ME site (shorter) on Genes

Discussion in 'Fibromyalgia Main Forum' started by sues1, Jun 11, 2006.

  1. sues1

    sues1 New Member

    A first study of cytokine genomic polymorphisms in CFS: Positive
    association of TNF-857 and IFNgamma 874 rare alleles.

    Journal: Clin Exp Rheumatol. 2006 Mar,Apr;24(2):179-182.

    N. Carlo-Stella [1], C. Badulli [2], A. De Silvestri [2], L. Bazzichi
    [3], M. Martinetti [2], L. Lorusso [4], S. Bombardieri [3],
    L.Salvaneschi [2], M. Cuccia [1]

    Affiliations: [1] University of Pavia, [2] San Matteo Polyclinic
    Hospital, Pavia; [3] S. Chiara Hospital, Pisa; [4] M. Mellini
    Hospital, Chiari, (BS), Italy.

    PMID: 16762155

    OBJECTIVE: In the past two years we have developed a biological bank
    of genomic DNA, cDNA, serum and red blood cells of Italian patients
    with certified CFS from the two Italian referral centers for the
    syndrome. Recent studies have shown an imbalance in cytokine
    production in disease states similar to Chronic Fatigue Syndrome
    (CFS), such as sickness behavior, both in animals and in humans.
    However we notice that serum cytokine concentrations are often
    inconstant and degrade rapidly. With this in mind, we investigated
    cytokine gene polymorphisms in 80 Italian patients with CFS in order
    to ascertain whether in this group of patients it is possible to
    describe a genetic predisposition to an inflammatory response.

    METHODS: We analyzed the promoter polymorphisms of IL-10, IL-6 and the
    IFNgamma 874 T/A polymorphism in intron 1 with a PCR-SSP method
    (Cytogen One Lambda Inc. Canoga Park, CA, U.S.A) in 54 patients and
    TNF-308 G/A and -857 C/T promoter polymorphisms with a PCR-RFLP method
    (in 54 and 80 patients respectively).

    RESULTS: There is a highly significant increase of TNF -857 TT and CT
    genotypes (p = 0.002) among patients with respect to controls and a
    significant decrease of IFN gamma low producers (A/A) (p = 0.04) among
    patients with respect to controls.

    CONCLUSIONS: We hypothesize that CFS patients can have a genetic
    predisposition to an immunomodulatory response of an inflammatory
    nature probably secondary to one or more environmental insults of
    unknown nature.

  2. elliespad

    elliespad Member

    That our DD's are caused by 1) a Genetic predisposition to faulty Glutathione, and 2) SIGNIFICANT EXPOSURE to toxic chemicals, usually Pesticides.

    This was THEIR conclusiton to the study:

    CONCLUSIONS: We hypothesize that CFS patients can have a genetic
    predisposition to an immunomodulatory response of an inflammatory
    nature probably secondary to one or more environmental insults of
    unknown nature.
  3. sues1

    sues1 New Member

    elliespad

    that was what stood out to me....the conclusion says alot.

    Susan

[ advertisement ]