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Discussion in 'Lyme Disease Archives' started by tansy, Nov 28, 2007.

  1. tansy

    tansy New Member

    1: Rev Neurol (Paris). 2007 Nov;163(11):1039-47.

    [Acute myelitis and Lyme disease.]

    [Article in French]

    Blanc F, Froelich S, Vuillemet F, Carre S, Baldauf E, De Martino S,
    Jaulhac B,
    Maitrot D, Tranchant C, De Seze J.

    Departement de neurologie, hopitaux universitaires de Strasbourg,
    Strasbourg.

    Introduction. Acute myelitis accounts for 4 to 5 percent of all cases of
    neuroborreliosis. In the literature, simultaneous spinal MRI and
    cerebrospinal
    fluid (CSF) investigations are presented for only 8 cases. We describe
    here 3
    cases of acute Lyme myelitis. Method. In a cohort of 45 patients with
    neuroborreliosis, diagnosed between January 1998 and January 2005, 3 had
    acute
    myelitis. Clinical, biological and radiological data were studied. Case
    reports.
    The three patients had motor, sensorial and sphincter involvement.
    Extra-spinal
    involvement, such as fever and headache for one, facial nerve palsy for the
    second and subarachnoid hemorrhage for the third, was also noted.
    Pleocytosis
    varied from 10 to 520 white cells per mm3. Lyme serology was positive in
    CSF for
    all. Intrathecal anti-Borrelia antibody index was positive or
    intermediate for
    all three patients. Spinal cord MRI revealed a large hyperintense zone
    involving
    more than 3 vertebral segments. Myelitis was central, posterior or
    transverse in
    the axial plane. The clinical course was favorable after a three-week
    course of appropriate antibiotics.

    CONCLUSION: These 3 cases and the others from the
    literature show the diversity of the clinical and radiological features
    of acute
    myelitis: transverse, central or posterior myelitis. Thus, Lyme serology
    in CSF
    in indicated for patients presenting acute myelitis, particularly in
    endemic areas.

    Publication Types:
    English Abstract

    PMID: 18033042 [PubMed - in process]

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    2: Vestn Ross Akad Med Nauk. 2007;(9):16-9.

    [Peculiarities of cytokine regulation in tick-borne encephalitis and
    Lyme borreliosis]

    [Article in Russian]

    [No authors listed]

    The aim of the study was to evaluate the dynamics of T-lymphocyte cytokine
    profile during the acute period of tick-bore encephalitis (febrile and
    meningeal
    forms) and non-erythematous Lyme borreliosis (NELB). ELISA (Vector-Best,
    Novosybirsk) and IHA (Virion, Tomsk) techniques were used for laboratory
    diagnostics of tick-borne encephalitis (TBE). Etiological verification
    of Lyme
    borreliosis (LB) was performed using immune-enzyme test systems for
    detection of
    IgG and IgM antibodies to Borellia burgdorferi (NOVATEC Immunodiagnostica,
    Germany). Thirty-eight subjects constituted the meningeal TBE group; the
    febrile
    TBE group consisted of 25 subjects. NELB was diagnosed in 20 subjects.
    Immunological tests were performed on days 1-7, 8-14, 15-21, and 22-28
    of the
    disease. The study found that primary T-lymphocytes prevailed at early
    stages
    during the acute period of febrile TBE. In NELB, secondary T-lymphocytes
    were
    registered beginning from days 15-21. Meningeal TBE was characterized by
    a deep
    reduction in IFNgamma-producing CD3+ lymphocyte reserve.

    Publication Types:
    English Abstract

    PMID: 18030714 [PubMed - in process]

    -------

    3: Proc Biol Sci. 2007 Nov 20; [Epub ahead of print]

    Conspicuous impacts of inconspicuous hosts on the Lyme disease epidemic.

    Brisson D, Dykhuizen DE, Ostfeld RS.

    Department of Biology, University of Pennsylvania, Leidy Laboratories,
    326, 433
    South University Avenue, Philadelphia, PA 19104-6018, USA.

    Emerging zoonotic pathogens are a constant threat to human health
    throughout the
    world. Control strategies to protect public health regularly fail, due
    in part
    to the tendency to focus on a single host species assumed to be the primary
    reservoir for a pathogen. Here, we present evidence that a diverse set of
    species can play an important role in determining disease risk to humans
    using
    Lyme disease as a model. Host-targeted public health strategies to
    control the
    Lyme disease epidemic in North America have focused on interrupting Borrelia
    burgdorferi sensu stricto (ss) transmission between blacklegged ticks
    and the
    putative dominant reservoir species, white-footed mice. However, B.
    burgdorferi
    ss infects more than a dozen vertebrate species, any of which could
    transmit the
    pathogen to feeding ticks and increase the density of infected ticks and
    Lyme
    disease risk. Using genetic and ecological data, we demonstrate that
    mice are
    neither the primary host for ticks nor the primary reservoir for B.
    burgdorferi
    ss, feeding 10% of all ticks and 25% of B. burgdorferi-infected ticks.
    Inconspicuous shrews feed 35% of all ticks and 55% of infected ticks.
    Because
    several important host species influence Lyme disease risk, interventions
    directed at a multiple host species will be required to control this
    epidemic.

    PMID: 18029304 [PubMed - as supplied by publisher]


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    4: J Neurol Neurosurg Psychiatry. 2007 Dec;78(12):1409-10.

    Retrobulbar optic neuritis: a complication of Lyme disease?

    Krim E, Guehl D, Burbaud P, Lagueny A.

    Publication Types:
    Letter

    PMID: 18024698 [PubMed - in process]

    -------

    5: Vector Borne Zoonotic Dis. 2007 Nov 20; [Epub ahead of print]

    Borrelia burgdorferi Sensu Lato in Siberian Chipmunks (Tamias sibiricus)
    Introduced in Suburban Forests in France.

    Vourc'h G, Marmet J, Chassagne M, Bord S, Chapuis JL.

    National Institute for Agricultural Research (INRA), UR346 Animal
    Epidemiology,
    F-63122 Saint Genes Champanelle, France.

    Numerous vertebrate reservoirs have been described for Borrelia burgdorferi
    sensu lato (sl), which includes the etiological agents of Lyme
    Borreliosis (LB).
    The Siberian chipmunk (Tamias sibiricus) is a rodent originating from Asia,
    where it is suspected to be a B. burgdorferi reservoir. It has been
    intentionally released into the wild in Europe since the 1970s, but has
    not yet
    been subject to any study regarding its association with the LB agent.
    In this
    paper we studied Siberian chipmunk infestation with the LB vector (Ixodes
    ricinus) and infection prevalence by LB spirochetes in a suburban introduced
    population. We compared these findings with known competent reservoir
    hosts, the
    bank vole (Myodes [clethrionomys] glareolus) and wood mouse (Apodemus
    sylvaticus). All Siberian chipmunks were infested with larvae and larval
    abundance was higher in this species (mean number of larvae [95% Confidence
    Interval]: 73.5 [46.0, 117.2]) than in the two other rodent species
    (bank voles:
    4.4 [3.0, 6.3] and wood mice: 10.2 [4.9, 21.2]). Significant factors
    affecting
    abundance of larvae were host species and sampling season. Nymphs were most
    prevalent on chipmunks (86.2%, mean: 5.1 [3.3, 8.0]), one vole carried
    only two
    nymphs, and none of the mice had any nymphs. Nymph abundance in
    chipmunks was
    affected by sampling season and sex. Furthermore, the infection
    prevalence of B.
    burgdorferi sl in the Siberian chipmunk was the highest (33.3%) and
    predominantly of B. afzelii. The infection prevalence was 14.1% in bank
    voles,
    but no wood mouse was found to be infected. Our results suggest that the
    Siberian chipmunk may be an important reservoir host for LB.

    PMID: 18021026 [PubMed - as supplied by publisher]

    ------

    6: Am Fam Physician. 2007 Nov 1;76(9):1314-22.

    Pet-related infections.

    Rabinowitz PM, Gordon Z, Odofin L.

    Yale University School of Medicine, New Haven, Connecticut 06510, USA.
    Peter.Rabinowitz@...

    Human contact with cats, dogs, and other pets results in several million
    infections each year in the United States, ranging from self-limited skin
    conditions to life-threatening systemic illnesses. Toxoplasmosis is one
    of the
    most common pet-related parasitic infections. Although toxoplasmosis is
    usually
    asymptomatic or mild, it may cause serious congenital infection if a
    woman is
    exposed during pregnancy, particularly in the first trimester. Common
    pet-borne
    fungal infections include tinea corporis/capitis (ringworm);
    campylobacteriosis
    and salmonellosis are among the most common bacterial infections
    associated with
    pet ownership. Less commonly, pets can transmit arthropod-borne and viral
    illnesses (e.g., scabies, rabies). Infection in a pet can provide sentinel
    warning of local vectors and endemic conditions, such as Lyme disease risk.
    Treatment is infection-specific, although many infections are self-limited.
    Prevention involves common sense measures such as adequate hand washing,
    proper
    disposal of animal waste, and ensuring that infected animals are
    diagnosed and
    treated. Special precautions are indicated for immunocompromised persons.
    Increased communication between primary care physicians and
    veterinarians could
    improve treatment and prevention of these conditions.

    PMID: 18019874 [PubMed - in process]
  2. victoria

    victoria New Member

    good info Tansy......
  3. klutzo

    klutzo New Member

    Hi Tansy,
    In the first article, I can't tell if they are saying that only the acute myelitis was resolved after three weeks of ABX, or if they are saying the neuroborreliosis itself was resolved. If it's the later, it is not good news for those of us with chronic Lyme. It would just be more for the other camp to use against us.

    Klutzo