MRI study: brainstem dysfunction

Discussion in 'Fibromyalgia Main Forum' started by tansy, Mar 2, 2011.

  1. tansy

    tansy New Member


    http://sacfs.asn.au/news/2011/03/03_01_publication_of_original_adelaide_cfs_mri_study.htm
    Publication of original Adelaide CFS MRI study
    Tuesday 1 March 2011

    An MRI study which detected brainstem dysfunction and altered
    homeostasis in people with CFS is about to be published in the medical
    journal NMR in Biomedicine.

    Here's a preview:


    A brain MRI study of chronic fatigue syndrome: Evidence of brainstem
    dysfunction and altered homeostasis

    Authors: Leighton R. Barnden, Benjamin Crouch, Richard Kwiatek, Richard
    Burnet, Anacleto Mernone, Steve Chryssidis, Garry Scroop, Peter Del
    Fante

    Publication: NMR in Biomedicine

    Abstract [accepted, pre-proof]

    To explore brain involvement in chronic fatigue syndrome (CFS), we have
    extended statistical parametric mapping of brain magnetic resonance (MR)
    images to whole-brain voxel-based regressions against clinical scores.

    Using SPM5 we performed voxel-based morphometry (VBM) and analysed T1-
    and T2-weighted spin-echo MR signal levels in 25 CFS subjects and 25
    normal controls (NC). Clinical scores included CFS fatigue duration, a
    score based on the 10 most common CFS symptoms, the Bell score, HADS
    anxiety and depression, and hemodynamic parameters from 24 hour blood
    pressure monitoring.

    We also performed group =D7 hemodynamic score
    interaction regressions to detect locations where MR regressions were
    opposite for CFS and NC, thereby indicating abnormality in the CFS
    group. In the midbrain, white matter volume was observed to decrease
    with increasing fatigue duration. For T1-weighted MR and white matter
    volume, group =D7 hemodynamic score interactions were detected in the
    brainstem (strongest in midbrain grey matter), deep prefrontal white
    matter, the caudal basal pons and hypothalamus.

    A strong correlation in CFS between brainstem grey matter volume and pulse pressure suggested impaired cerebrovascular autoregulation. We argue that at least some of
    these changes could arise from astrocyte dysfunction. These results are
    consistent with an insult to the midbrain at fatigue onset that affects
    multiple feedback control loops to suppress cerebral motor and cognitive
    activity and disrupt local CNS homeostasis, including resetting of some
    elements of the autonomic nervous system.

    Copyright =A9 2011 John Wiley& Sons, Ltd.
  2. quanked

    quanked Member

    I don't understand much of the abstract but what I do get is that this may further support our belief that CFIDS/ME is physiologically based rather than a psychological problem.

    I hope this study makes it into mainstream media.
  3. tansy

    tansy New Member

    Hi Quanked. For those who find information processing difficult this sentence explains the study's significance.

    These results are consistent with an insult to the midbrain at fatigue onset that affects multiple feedback control loops to suppress cerebral motor and cognitive activity and disrupt local CNS homeostasis, including resetting of some elements of the autonomic nervous system.