I have been so burned out from trying sooooooooooo many different kinds of supplements, drugs, therapies, etc. to help with my FM, I was ready to really give up until I came up with a really good combination for me, this took me 20 years and probably thousands of dollars later, but I am getting better. MSM has been the most promising supplement for me as to date. I take: CoQ10 150 mg's in the morning (my CoQ10 also contains B12 and 250 mg's of vitamic C) Omega 3 oils, 1000 mg's in the morning MSM 400 mg in the afternoon, and again in the early evening, total so far 800 mg's per day 10 billion units of a probiotic before bedtime 300 mg's of Natural Calm Magnesium Citrate mix two hours before bed ( I sleep better with this) I started eating apples, yogurt and blueberries instead of junky foods for my snacks and I drink a lot of water. So far, this regimen has really helped me that I am now able to exercise on my bike for 15 minutes a day, although the exercise can still be challenging, I wouldn't have dreamed of going on it even a year ago. MSM, and Magnesium I believe are the real winners in this combination for me. MSM is sulfur and is a natural anti-inflammatory. Even though I have heard many times before that FM is not an inflammatory condition, I disagree. I constantly feel inflammed from my head to my toes, but taking the MSM and magnesium has helped so much, I just couldn't believe it. I was taking Vitamin D, but really wasn't noticing any benefit from it, I may still add it because of lack of sun exposure, but it wasn't a "feel the difference" product for me. Of course with FM, there hasn't been anything to make me 100 percent (don't we wish) better, but I have a demanding job, and this supplment cocktail has improbed me over 50%, maybe more. Just wanted to share with you. Hugs, Chelz.