MSM along with vitamin C and Calcium everyday has changed the way I feel!!! MSM is all natural and is best if taken in powder (as apposed to capsule) form. The vitamin C helps the MSM to work. Calcium eliminates GERDS/heartburn! I take 1 or 2 tsps. of MSM 2 times per day mixed in juice or soda (it is very bitter), 1 tsp. of vitamin C daily and CORAL Calcium according to the directions on the bottle. CORAL Calcium from Okinawa, Japan is the kind to get. It has nothing but Calcium/no other added vitamins. The first 3 or 4 days or so when all the toxins are leaving your body you will feel flu-like, but after that you will be amazed at having less pain and more energy!! A friend of mine bought the stuff and that's the only reason I tried it. Now he made me a believer!!!