Multiple strains of LYME in one mouse... RESEARCH

Discussion in 'Lyme Disease Archives' started by victoria, Apr 15, 2008.

  1. victoria

    victoria New Member

    this is why more than 1 abx is likely needed, besides the probability of co-infections:

    From Lyme Info yahoo group:

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    "These results confirmed that mice in southern Maryland were persistently infected with multiple variants of B. burgdorferi throughout the transmission season."

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    Presence of Multiple Variants of Borrelia burgdorferi in the Natural Reservoir Peromyscus leucopus Throughout a Transmission Season

    Katherine I. Swanson, Douglas E. Norris. Vector-Borne and Zoonotic Diseases. 2008 Apr 9 (Epub ahead of print.)

    doi:10.1089/vbz.2007.0222.

    http://dx.doi.org/10.1089/vbz.2007.0222

    *Abstract*

    White-footed mice (Peromyscus leucopus) serve as the principal reservoir for Borrelia burgdorferi and have been shown to remain infected for life.

    Complex infections with multiple genetic variants of B. burgdorferi occur in mice through multiple exposures to infected ticks or through exposure to ticks infected with multiple variants of B. burgdorferi.

    Using a combination of cloning and single strand conformation polymorphism (SSCP), B. burgdorferi ospC variation was assessed in serial samples collected from individual P. leucopus during a single transmission season.

    In individuals with ospC variation, at least seven ospC variants were recognized at each time point. 1-4 of these variants predominated at each time point; however, the predominant variants seldom remained consistent in an individual mouse throughout the entire sampling period.

    These results confirmed that mice in southern Maryland were persistently infected with multiple variants of B. burgdorferi throughout the transmission season.

    However, the presence of multiple ospC variants and the fluctuations in the frequency of these variants indicates that either new ospC variants are regularly introduced to this mouse population and predominate while the existing infections are cleared,

    or that the variation detected in the genetic profile at different time points reflects a complex mixture of B. burgdorferi populations whose relative frequencies may continually change.

    http://dx.doi.org/10.1089/vbz.2007.0222

  2. munch1958

    munch1958 Member

    I'm not surprised!! I know I've had at least two EM rashes and a third rash of creeping crud on my hands from trips to different states.
  3. connieaag

    connieaag New Member

    I read that too. From what I have learned, which is not nearly what some on here know, it always shows the different strands under a microscope for comparison. I don't know that there is a specific test, but would be curious to the answer too!
  4. victoria

    victoria New Member

    testing is not even reliable for showing lyme, much less what strain... so from all I've read, my opinion is, one just has to keep trying different abx.

    Not only because of different strains of lyme, but also because of co-infections that are even hard to test for.